Terrien, a metabolite made by Aspergillus terreus , has activity against Cryptococcus neoformans .

Autor:	Cadelis M; School of Chemical Sciences, University of Auckland, Auckland, New Zealand.; Bioluminescent Superbugs Lab, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand., Grey A; Bioluminescent Superbugs Lab, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand., van de Pas S; Bioluminescent Superbugs Lab, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand., Geese S; Bioluminescent Superbugs Lab, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand., Weir BS; Manaaki Whenua - Landcare Research, Auckland, New Zealand., Copp B; School of Chemical Sciences, University of Auckland, Auckland, New Zealand., Wiles S; Bioluminescent Superbugs Lab, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
Jazyk:	angličtina
Zdroj:	PeerJ [PeerJ] 2022 Oct 18; Vol. 10, pp. e14239. Date of Electronic Publication: 2022 Oct 18 (Print Publication: 2022).
DOI:	10.7717/peerj.14239
Abstrakt:	Antimicrobial compounds, including antibiotics, have been a cornerstone of modern medicine being able to both treat infections and prevent infections in at-risk people, including those who are immune-compromised and those undergoing routine surgical procedures. Their intense use, including in people, animals, and plants, has led to an increase in the incidence of resistant bacteria and fungi, resulting in a desperate need for novel antimicrobial compounds with new mechanisms of action. Many antimicrobial compounds in current use originate from microbial sources, such as penicillin from the fungus Penicillium chrysogenum (renamed by some as P. rubens ). Through a collaboration with Aotearoa New Zealand Crown Research Institute Manaaki Whenua-Landcare Research we have access to a collection of thousands of fungal cultures known as the International Collection of Microorganisms from Plants (ICMP). The ICMP contains both known and novel species which have not been extensively tested for their antimicrobial activity. Initial screening of ICMP isolates for activity against Escherichia coli and Staphylococcus aureus directed our interest towards ICMP 477, an isolate of the soil-inhabiting fungus, Aspergillus terreus . In our investigation of the secondary metabolites of A. terreus , through extraction, fractionation, and purification, we isolated nine known natural products. We evaluated the biological activity of selected compounds against various bacteria and fungi and discovered that terrein ( 1 ) has potent activity against the important human pathogen Cryptococcus neoformans . Competing Interests: Siouxsie Wiles is an Academic Editor for PeerJ. (© 2022 Cadelis et al.)
Databáze:	MEDLINE
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