A pilot study comparing myelin measurements from myelin water imaging and 11 C-PIB PET in multiple sclerosis.

Autor: Vavasour IM; Radiology, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada. Electronic address: lees@phas.ubc.ca., Vafai N; Medicine (Neurology), University of British Columbia, Vancouver, Canada., Beauchemin P; Département de Médecine, Université Laval, Ville de Québec, Canada., Kanjilal C; Physics & Astronomy, University of British Columbia, Vancouver, Canada., Badalan A; Physics & Astronomy, University of British Columbia, Vancouver, Canada., Shahinfard E; Medicine (Neurology), University of British Columbia, Vancouver, Canada., Laule C; Radiology, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada; Physics & Astronomy, University of British Columbia, Vancouver, Canada; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada., Li DK; Radiology, University of British Columbia, Vancouver, Canada., Traboulsee A; Medicine (Neurology), University of British Columbia, Vancouver, Canada., Sossi V; Medicine (Neurology), University of British Columbia, Vancouver, Canada; Physics & Astronomy, University of British Columbia, Vancouver, Canada., Kolind SH; Radiology, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada; Medicine (Neurology), University of British Columbia, Vancouver, Canada; Physics & Astronomy, University of British Columbia, Vancouver, Canada., Carruthers RL; Medicine (Neurology), University of British Columbia, Vancouver, Canada.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2022 Dec; Vol. 68, pp. 104238. Date of Electronic Publication: 2022 Oct 17.
DOI: 10.1016/j.msard.2022.104238
Abstrakt: MRI-based myelin water fraction (MWF) and PET-based Pittsburgh compound B (PiB) imaging both have potential to measure myelin in multiple sclerosis (MS). We characterised the differences in MWF and PiB binding in MS lesions relative to normal-appearing white matter and assessed the correlation between MWF and PiB binding in 11 MS participants and 3 healthy controls within 14 white matter regions of interest. Both PiB binding and MWF were reduced in MS lesions relative to NAWM, and a modest within subject correlation between MWF and PiB binding was found. This pilot study shows that MWF and PET-PiB provide different information about myelin loss in MS.
Competing Interests: Declaration of Competing Interest IV, NV, CK, AB ES and VS have nothing to declare. PB has participated in advisory boards for Biogen Canada, Alexion Canada, Roche Canada, EMD Serono, Sanofi Genzyme and received speaker fees for Novartis, Roche Canada, Pendopharm and Alexion. CL has research support from NSERC, MS Society of Canada and the International Collaboration on Repair Discoveries. DL has acted as a consultant to Vertex Pharmaceuticals, served on the Scientific Advisory Boards for Adelphi Group, Biogen and Celgene and given lectures which have been supported by non-restricted education grants from Academy of Health Care Learning, Consortium of MS Centers and Sanofi-Genzyme. AT received funding from Chugai, Roche, Novartis, Genzyme, Biogen and received honoraria from Genzyme, Roche, Teva, Biogen and Serono. SK has received research funding from Sanofi Genzyme and F. Hoffmann La Roche. RC is Site Investigator for studies funded by Roche, Novartis, MedImmune, EMD Serono, receives research support from Teva Innovation Canada, Roche Canada and Vancouver Coastal Health Research Institute and received honoraria from Roche, EMD Serono, Sanofi, Biogen, Novartis, Alexion and Teva.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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