Neuropsychiatric outcomes and caregiver distress in primary progressive aphasia.

Autor: Seckin M; Department of Neurology, Acıbadem Mehmet Ali Aydınlar University School of Medicine, Istanbul, Turkey.; Acıbadem Mehmet Ali Aydınlar University School of Medicine, Alzheimer's Disease and Cognitive Neurology Research Lab, Istanbul, Turkey., Yıldırım E; Faculty of Economics, Administrative and Social Sciences, Department of Psychology, Işık University, Istanbul, Turkey., Demir İ; Department of Neuroscience, Istanbul University Aziz Sancar Institute of Experimental Medicine, Istanbul, Turkey.; Hulusi Behçet Life Sciences Center, Neuroimaging Lab, Istanbul University, Istanbul, Turkey., Orhun Ö; Acıbadem Mehmet Ali Aydınlar University School of Medicine, Alzheimer's Disease and Cognitive Neurology Research Lab, Istanbul, Turkey., Bülbül E; Acıbadem Mehmet Ali Aydınlar University School of Medicine, Alzheimer's Disease and Cognitive Neurology Research Lab, Istanbul, Turkey., Velioğlu HA; Health Sciences and Technology Research Institute (SABITA), Regenerative and Restorative Medicine Research Center (REMER), functional Imaging and Cognitive-Affective Neuroscience Lab (fINCAN), Istanbul Medipol University, Istanbul, Turkey., Öktem Ö; Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul University Faculty of Medicine, Istanbul, Turkey., Yeşilot N; Department of Neurology, Edip Aktin Stroke Unit, Istanbul University Faculty of Medicine, Istanbul, Turkey., Çoban O; Department of Neurology, Edip Aktin Stroke Unit, Istanbul University Faculty of Medicine, Istanbul, Turkey., Gürvit H; Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society [Psychogeriatrics] 2023 Jan; Vol. 23 (1), pp. 52-62. Date of Electronic Publication: 2022 Oct 23.
DOI: 10.1111/psyg.12902
Abstrakt: Background: In this study, we aimed to outline the neuropsychiatric consequences of primary progressive aphasia (PPA) and to understand how neuropsychiatric symptomatology affects distress in caregivers.
Methods: The Neuropsychiatric Inventory (NPI) including the distress index (NPI-Distress) was used. Additional information about the caregiver burden was obtained using Zarit Burden Interview (ZBI). NPI, NPI-Distress, and ZBI data from 17 patients with a clinical diagnosis of PPA were compared with 10 stroke aphasia patients. Neuropsychiatric symptomatology was investigated based on three clusters; Mood, Frontal/Comportmental, and Psychotic/Disruptive. Additionally, the Activities of Daily Living Questionnaire (ADLQ) was used to outline the functional impairment. Twelve healthy controls were included to compare the neurocognitive test scores with PPA and stroke aphasia groups.
Results: A greater number of neuropsychiatric symptoms were observed in the PPA group compared to the stroke aphasia group. The number of symptoms in Mood, and Frontal/Comportmental clusters were greater than the number of symptoms in Psychotic/Disruptive clusters in the PPA group, whereas no significant relationship between the number of symptoms and symptom clusters was found in the stroke aphasia group. In the PPA group, a strong correlation was found between the NPI-Frequency × Severity scores and the NPI-Distress scores. Moreover, the NPI-Distress scores in the PPA group strongly correlated with the ZBI scores. Scores for anxiety, irritability/lability, and apathy had a stronger correlation with the NPI-Distress scores compared to the other NPI symptoms. The Communication subscale was the most impaired domain in the PPA group. Travel, and Employment and Recreation subscales showed greater functional impairment in the stroke aphasia group compared to the PPA group.
Conclusions: Neuropsychiatric symptoms in PPA in our study were more frequent than previously reported. Furthermore, the distress index of the NPI was not only correlated with the severity of the neuropsychiatric symptoms but also reflected the overall burden on the caregivers in the PPA group.
(© 2022 Japanese Psychogeriatric Society.)
Databáze: MEDLINE
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