Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.

Autor: Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA. berndts@mail.nih.gov., Vijai J; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Benavente Y; Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., Camp NJ; Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Nieters A; Institute for Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany., Wang Z; Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Smedby KE; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Hematology Center, Karolinska University Hospital, Stockholm, Sweden., Kleinstern G; School of Public Health, University of Haifa, Haifa, Israel., Hjalgrim H; Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Haematology, Rigshospitalet, Copenhagen, Denmark.; Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Besson C; Centre Hospitalier de Versailles, Le Chesnay, France.; Université Paris-Saclay, UVSQ, Inserm, Équipe 'Exposome et Hérédité', CESP, Villejuif, France., Skibola CF; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA., Morton LM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Brooks-Wilson AR; Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada., Teras LR; Department of Population Science, American Cancer Society, Atlanta, GA, USA., Breeze C; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Arias J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Adami HO; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Institute of Health and Society, Clinical Effectiveness Research Group, University of Oslo, Oslo, Norway., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Anderson KC; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Ansell SM; Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Bassig B; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Becker N; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany., Bhatti P; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Birmann BM; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Boffetta P; Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, 11794, NY, USA.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, 41026, Italy., Bracci PM; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA., Brennan P; International Agency for Research on Cancer (IARC), Lyon, France., Brown EE; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Burdett L; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MA, USA., Cannon-Albright LA; Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA., Chang ET; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.; Center for Health Sciences, Exponent, Inc., Menlo Park, CA, USA., Chiu BCH; Department of Public Health Sciences University of Chicago, Chicago, IL, USA., Chung CC; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Clavel J; CRESS, UMR1153, INSERM, Villejuif, France.; Université de Paris-Cité, Villejuif, France., Cocco P; Centre for Occupational and Environmental Health, Division of Population Science, Health Services Research & Primary Care, University of Manchester, Manchester, United Kingdom., Colditz G; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA., Conde L; Bill Lyons Informatics Centre, UCL Cancer Institute, University College London, London, United Kingdom., Conti DV; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Cox DG; INSERM U1052, Cancer Research Center of Lyon, Centre Léon Bérard, Lyon, France., Curtin K; Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Casabonne D; Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., De Vivo I; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Diepstra A; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Diver WR; Department of Population Science, American Cancer Society, Atlanta, GA, USA., Dogan A; Departments of Laboratory Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Edlund CK; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Foretova L; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Fraumeni JF Jr; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Gabbas A; Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari, Italy., Ghesquières H; Department of Hematology, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre Benite, France.; CIRI, Centre International de Recherche en Infectiologie, Team Lymphoma Immuno-Biology, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France., Giles GG; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VC, Australia., Glaser S; Cancer Prevention Institute of California, Fremont, CA, USA.; Stanford Cancer Institute, Stanford, CA, USA., Glenn M; Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Glimelius B; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Gu J; Department of Epidemiology, MD Anderson Cancer Center, Houston, TX, USA., Habermann TM; Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Haiman CA; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Haioun C; Lymphoid Malignancies Unit, Henri Mondor Hospital and University Paris Est, Créteil, France., Hofmann JN; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Holford TR; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Holly EA; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA., Hutchinson A; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MA, USA., Izhar A; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jackson RD; Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, USA., Jarrett RF; MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom., Kaaks R; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany., Kane E; Department of Health Sciences, University of York, York, United Kingdom., Kolonel LN; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Kong Y; Information Systems and Decision Sciences, California State University, Fullerton, Fullerton, CA, USA., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Kricker A; Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia., Lake A; MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom., Lan Q; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Lawrence C; Westat, Rockville, MA, USA., Li D; F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Liebow M; Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Link BK; Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA., Magnani C; CPO-Piemonte and Unit of Medical Statistics and Epidemiology, Department Translational Medicine, University of Piemonte Orientale, Novara, Italy., Maynadie M; INSERM U1231, EA 4184, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon, France., McKay J; International Agency for Research on Cancer (IARC), Lyon, France., Melbye M; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Jebsen Center for Genetic epidemiology, NTNU, Trondheim, Norway.; Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Genetics, Stanford University Medical School, Stanford, CA, USA., Miligi L; Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy., Milne RL; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VC, Australia., Molina TJ; Department of Pathology, APHP, Necker and Robert Debré, Université Paris Cité, Institut Imagine, INSERM U1163, Paris, France., Monnereau A; CRESS, UMR1153, INSERM, Villejuif, France.; Registre des hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux, Cedex, France., Montalvan R; Westat, Rockville, MA, USA., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Novak AJ; Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Onel K; Donald and Barbara Zucker School of Medicine, Hofstra/Northwell, Hempstead, New York, NY, USA., Purdue MP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Rand KA; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Riboli E; School of Public Health, Imperial College London, London, United Kingdom., Riby J; Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.; Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA, USA., Roman E; Department of Health Sciences, University of York, York, United Kingdom., Salles G; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sborov DW; Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Severson RK; Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI, USA., Shanafelt TD; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Smith MT; Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA, USA., Smith A; Department of Health Sciences, University of York, York, United Kingdom., Song KW; Leukemia/Bone Marrow Transplantation Program, BC Cancer Agency, Vancouver, BC, Canada.; Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Song L; Center for Cancer Research, National Cancer Institute, Frederick, MA, USA., Southey MC; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VC, Australia.; Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, VC, 3010, Australia., Spinelli JJ; Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada., Staines A; School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland., Stephens D; Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Sutherland HJ; Leukemia/Bone Marrow Transplantation Program, BC Cancer Agency, Vancouver, BC, Canada.; Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Tkachuk K; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Thompson CA; Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Tilly H; Centre Henri Becquerel, Université de Rouen, Rouen, France., Tinker LF; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Travis RC; Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom., Turner J; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.; Department of Histopathology, Douglass Hanly Moir Pathology, Sydney, NSW, Australia., Vachon CM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Vajdic CM; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia., Van Den Berg A; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Van Den Berg DJ; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Vermeulen RCH; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Vineis P; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.; Human Genetics Foundation, Turin, Italy., Wang SS; Division of Health Analytics, City of Hope Beckman Research Institute, Duarte, CA, USA., Weiderpass E; International Agency for Research on Cancer (IARC), Lyon, France., Weiner GJ; Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA., Weinstein S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Doo NW; Concord Clinical School, University of Sydney, Concord, NSW, Australia., Ye Y; Department of Epidemiology, MD Anderson Cancer Center, Houston, TX, USA., Yeager M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MA, USA., Yu K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Zeleniuch-Jacquotte A; Department of Population Health, New York University School of Medicine, New York, NY, USA.; Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.; Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, USA., Zhang Y; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA., Zheng T; Department of Epidemiology, Brown University, Providence, RI, USA., Ziv E; Division of General Internal Medicine, Department of Medicine, Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Sampson J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA., Chatterjee N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MA, USA.; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MA, USA., Offit K; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cozen W; 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Jazyk: angličtina
Zdroj: Leukemia [Leukemia] 2022 Dec; Vol. 36 (12), pp. 2835-2844. Date of Electronic Publication: 2022 Oct 22.
DOI: 10.1038/s41375-022-01711-0
Abstrakt: Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10 -8 ) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10 -9 ). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10 -8 ), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.
(© 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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