New perspectives into the vaginal microbiome with systems biology.

Autor: Lee CY; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Dillard LR; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, USA., Papin JA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA., Arnold KB; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: kbarnold@umich.edu.
Jazyk: angličtina
Zdroj: Trends in microbiology [Trends Microbiol] 2023 Apr; Vol. 31 (4), pp. 356-368. Date of Electronic Publication: 2022 Oct 19.
DOI: 10.1016/j.tim.2022.09.011
Abstrakt: The vaginal microbiome (VMB) is critical to female reproductive health; however, the mechanisms associated with optimal and non-optimal states remain poorly understood due to the complex community structure and dynamic nature. Quantitative systems biology techniques applied to the VMB have improved understanding of community composition and function using primarily statistical methods. In contrast, fewer mechanistic models that use a priori knowledge of VMB features to develop predictive models have been implemented despite their use for microbiomes at other sites, including the gastrointestinal tract. Here, we explore systems biology approaches that have been applied in the VMB, highlighting successful techniques and discussing new directions that hold promise for improving understanding of health and disease.
Competing Interests: Declaration of interests No interests are declared.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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