| Autor: |
Chen YC; National Laboratory for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China., Lei LJ; National Laboratory for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China., Xiao TM; National Laboratory for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China., Xu YN; National Laboratory for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China., Xing JG; Xinjiang Key Laboratory of Uighur Medicine, Urumqi 830002, China.; Department of Pharmaceutics, Xinjiang Institute of Materia Medica, Urumqi 830002, China., Si SY; National Laboratory for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China., Zheng RF; Xinjiang Key Laboratory of Uighur Medicine, Urumqi 830002, China.; Department of Pharmaceutics, Xinjiang Institute of Materia Medica, Urumqi 830002, China., Chen MH; National Laboratory for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Xinjiang Key Laboratory of Uighur Medicine, Urumqi 830002, China.; Department of Pharmaceutics, Xinjiang Institute of Materia Medica, Urumqi 830002, China. |
| Abstrakt: |
In this paper, we present the discovery of a novel salicylic acid derivative, moldavica acid A ( 1 ), and a new natural dibenzo[b,f]oxepin, moldavica acid B ( 2 ), together with four known phenylpropionic acids ( 3 - 6 ) and protocatechuic acid ( 7 ) that were isolated from Dracocephalum moldavica L. Their structures were elucidated by comprehensive spectroscopic methods, including infrared and nuclear magnetic resonance. Compound 1 is the first example of salicylic acid linking a carboxylated α -pyrone via an ethyl bridge. Beyond expanding the knowledge of the chemical diversity of D. moldavica , both compounds 1 and 2 were shown to upregulate the expression of Kruppel-like factor 2, which could serve as a prospective therapeutic target for the treatment of atherosclerosis. |
