Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials.

Autor: Mortberg MA; McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, 02142, USA., Vallabh SM; McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, 02142, USA., Minikel EV; McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA. eminikel@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, 02142, USA. eminikel@broadinstitute.org.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Oct 21; Vol. 12 (1), pp. 17708. Date of Electronic Publication: 2022 Oct 21.
DOI: 10.1038/s41598-022-21820-1
Abstrakt: Neurodegenerative disease is increasingly prevalent and remains without disease-modifying therapies. Engaging the right target, at the right disease stage, could be an important determinant of success. We annotated targets and eligibility criteria for 3238 neurodegenerative disease trials registered at ClinicalTrials.gov from 2000 to 2020. Trials became more selective as the mean number of inclusion and exclusion criteria increased and eligible score ranges shrank. Despite a shift towards less impaired participants, only 2.7% of trials included pre-symptomatic individuals; these were depleted for drug trials and enriched for behavioral interventions. Sixteen novel, genetically supported therapeutic hypotheses tested in drug trials represent a small, non-increasing fraction of trials, and the mean lag from genetic association to first trial was 13 years. Though often linked to disease initiation, not progression, these targets were tested mostly at symptomatic disease stages. The potential for disease modification through early intervention against root molecular causes of disease remains largely unexplored.
(© 2022. The Author(s).)
Databáze: MEDLINE
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