Synthesis of Glycyrrhizic Acid Conjugates with Amino-Acid Methyl Esters and their Ability to Stimulate Antibody Genesis in Mice.

Autor: Baltina LA; Ufa Institute of Chemistry, Branch of Ufa Federal Research Center, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, 450054 Russia., Baltina LA Jr; Ufa Institute of Chemistry, Branch of Ufa Federal Research Center, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, 450054 Russia., Petrova SF; Ufa Institute of Chemistry, Branch of Ufa Federal Research Center, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, 450054 Russia., Gabdrakhmanova SF; Ufa Institute of Chemistry, Branch of Ufa Federal Research Center, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, 450054 Russia., Makara NS; Ufa Institute of Chemistry, Branch of Ufa Federal Research Center, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, 450054 Russia., Sapozhnikova TA; Ufa Institute of Chemistry, Branch of Ufa Federal Research Center, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, 450054 Russia.
Jazyk: angličtina
Zdroj: Pharmaceutical chemistry journal [Pharm Chem J] 2022; Vol. 56 (7), pp. 894-898. Date of Electronic Publication: 2022 Oct 15.
DOI: 10.1007/s11094-022-02724-w
Abstrakt: Conjugates of glycyrrhizic acid (GA) with methyl esters of L -amino acids (valine, methionine, and glutamic acid) containing the amino-acid residues in the carbohydrate moiety of the glycoside were synthesized using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. The resulting GA conjugates at a dose of 2 mg/kg stimulated a primary immune response (production of antibody-forming cells, AFCs) in outbred mice by 1.6 - 3 times as compared with the control. The conjugate of GA with Glu(OMe) 2 stimulated antibody genesis in outbred mice 1.7 times more efficiently than N -acetylmuramyl dipeptide and showed a stimulating effect on AFC production in the spleen of CBA mice.
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Databáze: MEDLINE
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