Cytotoxicity of Hybrid Noble Metal-Polymer Composites.

Autor: Tkachenko A; Research Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv 61022, Ukraine.; Department of Biochemistry, Kharkiv National Medical University, Kharkiv 61022, Ukraine., Virych P; Faculty of Chemistry, Taras Shevchenko National University of Kyiv, Kyiv 01033, Ukraine., Myasoyedov V; Department of Medical Biology, Kharkiv National Medical University, Kharkiv 61022, Ukraine., Prokopiuk V; Research Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv 61022, Ukraine.; Department of Cryobiochemistry, Institute for Problems of Cryobiology and Cryomedicineof the National Academy of Sciences of Ukraine, Kharkiv 61015, Ukraine., Onishchenko A; Research Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv 61022, Ukraine.; Department of Biochemistry, Kharkiv National Medical University, Kharkiv 61022, Ukraine., Butov D; Department of Phthisiology and Pulmonology, Kharkiv National Medical University, Kharkiv 61022, Ukraine., Kuziv Y; Faculty of Chemistry, Taras Shevchenko National University of Kyiv, Kyiv 01033, Ukraine., Yeshchenko O; Faculty of Physic, Taras Shevchenko National University of Kyiv, Kyiv 01033, Ukraine., Zhong S; Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology, Yulin Normal University, Yulin 537000, China., Nie G; Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology, Yulin Normal University, Yulin 537000, China., Kutsevol N; Faculty of Chemistry, Taras Shevchenko National University of Kyiv, Kyiv 01033, Ukraine.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2022 Oct 11; Vol. 2022, pp. 1487024. Date of Electronic Publication: 2022 Oct 11 (Print Publication: 2022).
DOI: 10.1155/2022/1487024
Abstrakt: The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy. The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research. The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration. Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca 2+ -mediated pathways at the low concentration, in contrast to other studied materials. Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite. Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2022 Anton Tkachenko et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje