Pathogenicity & virulence of Histoplasma capsulatum - A multifaceted organism adapted to intracellular environments.
| Autor: | Valdez AF; Departamento de Microbiologia Geral, Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Paulo de Góes, Rio de Janeiro, Brazil., Miranda DZ; Departments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA., Guimarães AJ; Departamento de Microbiologia e Parasitologia - MIP, Universidade Federal Fluminense, Instituto Biomédico, Rio de Janeiro, Brazil., Nimrichter L; Departamento de Microbiologia Geral, Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Paulo de Góes, Rio de Janeiro, Brazil., Nosanchuk JD; Departments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Virulence [Virulence] 2022 Dec; Vol. 13 (1), pp. 1900-1919. |
| DOI: | 10.1080/21505594.2022.2137987 |
| Abstrakt: | Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus Histoplasma capsulatum . Although healthy individuals can develop histoplasmosis, the disease is particularly life-threatening in immunocompromised patients, with a wide range of clinical manifestations depending on the inoculum and virulence of the infecting strain. In this review, we discuss the established virulence factors and pathogenesis traits that make H. capsulatum highly adapted to a wide variety of hosts, including mammals. Understanding and integrating these mechanisms is a key step toward devising new preventative and therapeutic interventions. |
| Databáze: | MEDLINE |
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