A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine.

Autor: Corrêa HL; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil. hugo.efucb@gmail.com., Raab ATO; Faculty of Medicine, Catholic University of Brasilia, Brasília, Distrito Federal, Brazil., Araújo TM; Faculty of Bio-Medicine, Catholic University of Brasilia, Brasília, Distrito Federal, Brazil., Deus LA; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil., Reis AL; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil., Honorato FS; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil., Rodrigues-Silva PL; Embrapa Genetic Resources and Biotechnology, Brasilia, Distrito Federal, 70000-000, Brazil., Neves RVP; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil., Brunetta HS; Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil., Mori MADS; Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil.; Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil.; Experimental Medicine Research Cluster, University of Campinas, Campinas, Brazil., Franco OL; Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, DF, Brazil.; S-Inova Biotech, Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil., Rosa TDS; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil. thiagoacsdkp@yahoo.com.br.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Oct 20; Vol. 12 (1), pp. 17587. Date of Electronic Publication: 2022 Oct 20.
DOI: 10.1038/s41598-022-22123-1
Abstrakt: Klotho is an anti-aging protein with several therapeutic roles in the pathophysiology of different organs, such as the skeletal muscle and kidneys. Available evidence suggests that exercise increases Klotho levels, regardless of the condition or intervention, shedding some light on this anti-aging protein as an emergent and promising exerkine. Development of a systematic review and meta-analysis in order to verify the role of different exercise training protocols on the levels of circulating soluble Klotho (S-Klotho) protein. A systematic search of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE through PubMed, EMBASE, CINAHL, CT.gov, and PEDro. Randomized and quasi-randomized controlled trials that investigated effects of exercise training on S-Klotho levels. We included 12 reports in the analysis, comprising 621 participants with age ranging from 30 to 65 years old. Klotho concentration increased significantly after chronic exercise training (minimum of 12 weeks) (Hedge' g [95%CI] 1.3 [0.69-1.90]; P < 0.0001). Moreover, exercise training increases S-Klotho values regardless of the health condition of the individual or the exercise intervention, with the exception of combined aerobic + resistance training. Furthermore, protocol duration and volume seem to influence S-Klotho concentration, since the effect of the meta-analysis changes when subgrouping these variables. Altogether, circulating S-Klotho protein is altered after chronic exercise training and it might be considered an exerkine. However, this effect may be influenced by different training configurations, including protocol duration, volume, and intensity.
(© 2022. The Author(s).)
Databáze: MEDLINE
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