Serum pNF-H levels in the first six hours after experimental mild traumatic brain injury in rats.
| Autor: | Karesioglu E; Emergency Medicine Department, Bursa Uludağ University Medical Faculty, Bursa, Turkey. halilcikriklar@uludag.edu.tr., Cikriklar HI, Durak VA, Aydin B, Ardic A, Armagan E |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2022 Oct; Vol. 26 (19), pp. 6928-6934. |
| DOI: | 10.26355/eurrev_202210_29873 |
| Abstrakt: | Objective: Mild traumatic brain injury (mTBI) cases with a normal CT scanning account for the vast majority of all TBI patients. The aim of this study was to investigate the course of serum Phosphorylated Neurofilament Heavy Chain (pNF-H) levels in the first six hours after trauma in rats in experimental mTBI. Materials and Methods: In this experimental animal study, 32 female Sprague-Dawley rats were enrolled equally (n=8) into 3 experimental groups and 1 control group. In experimental groups, animals were exposed to a mTBI with a free fall of 50-gram metal disc from a height of 80 cm. We compared serum pNF-H levels at the 2nd, 4th, and 6th hours after traumatic brain injury in the experimental groups with the control group. Results: Serum pNF-H levels at the 2nd and 4th hours after traumatic brain injury were statistically significantly higher than the control group. Serum pNF-H levels gradually decreased at the 4th and 6th hours compared to the 2nd hour and decreased to a similar level to the control group at the 6th hour after injury. Conclusions: A high serum pNF-H value, could be used in the diagnosis and management of mTBI patients. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|