Serum 25-hydroxyvitamin D deficiency is associated with atopy, and sex may be an effect modifier of its association with asthma in teenagers from northeast Brazil.

Autor: Alcantara Galvão A; Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, Brazil., de Andrade Belitardo EMM; Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, Brazil., de Araújo Sena F; Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, Brazil., Santos JM; Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, Brazil., de Oliveira Costa GN; Instituto de Saúde Coletiva, Universidade Federal da Bahia (UFBA), Salvador, Brazil., Feitosa CA; Instituto de Saúde Coletiva, Universidade Federal da Bahia (UFBA), Salvador, Brazil.; Escola Baiana de Medicina e Saúde Pública, Salvador, Brazil., Fiaccone RL; Instituto de Matemática e Estatística, Universidade Federal da Bahia, Salvador, Brazil., Cruz ÁA; ProAR, Faculdade de Medicina, Universidade Federal da Bahia, (UFBA), Salvador, Brazil., Barreto ML; Instituto de Saúde Coletiva, Universidade Federal da Bahia (UFBA), Salvador, Brazil.; Centro de Integração de Dados e Conhecimentos Para a Saúde (CIDACS), Fiocruz, Brazil., Figueiredo CA; Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, Brazil., Alcantara-Neves NM; Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, Brazil.
Jazyk: angličtina
Zdroj: Pediatric pulmonology [Pediatr Pulmonol] 2023 Jan; Vol. 58 (1), pp. 297-305. Date of Electronic Publication: 2022 Nov 02.
DOI: 10.1002/ppul.26200
Abstrakt: Objective: Sufficient vitamin D (25-hydroxyvitamin D [25(OH)D]) serum levels are associated with decreased asthma symptoms. Our aim was to investigate associations between vitamin D and atopy, asthma, asthma severity, and asthma phenotypes in Brazilian teenagers.
Methods: This cross-sectional study involved 942 individuals (11-19 years old) engaged in an asthma cohort. The ISAAC questionnaire was employed to diagnosis asthma and asthma severity. Serum allergen-specific immunoglobulin E (sIgE) was measured by ImmunoCap and serum 25(OH)D was measured by ELISA. We calculated the correlation between sIgE and 25(OH)D. We used multivariate logistic regression analysis to assess associations of interest.
Results: We found that 25(OH)D deficiency was positively associated with atopy (OR 1.45, confidence interval [CI] 1.05-2.00) and high levels of this vitamin negatively correlated with sIgE to Dermatophagoides pteronyssinus (r = -0.11, p = 0.019). The average 25(OH)D serum level was 27.0 ± 9.5 ng/ml; 366 individuals (38.8%) had a sufficient level. There was no association between 25(OH)D and asthma, asthma severity or asthma phenotypes in the population. However, sex was a possible effect modifier of the association between vitamin D and asthma: insufficiency in asthmatic women (86%) was higher than in asthmatic men (42%), and there was an association between insufficient vitamin D levels and greater asthma risk only in women (OR = 3.06, 95% CI 1.16-8.07).
Conclusion: We have shown that vitamin D deficiency was associated with greater risk of atopy in both sexes and vitamin D insufficiency was associated with asthma only in women. There was no association between vitamin D levels and asthma phenotypes or asthma severity.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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