Lagerstroemia speciosa Ameliorated Blood Pressure in LNAME Induced Hypertension in Experimental Rats through NO/cGMP and Oxidative Stress Modulation.

Autor: Aleissa MS; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia., Al-Zharani M; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia., Alneghery LM; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia., Hasnain MS; Department of Pharmacy, Palamau Institute of Pharmacy, Chianki, Daltonganj, 822102 Jharkhand, India., Almutairi B; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia., Ali D; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia., Alarifi S; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia., Alkahtani S; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2022 Oct 10; Vol. 2022, pp. 5894416. Date of Electronic Publication: 2022 Oct 10 (Print Publication: 2022).
DOI: 10.1155/2022/5894416
Abstrakt: Cardiovascular disease is the primary reason for chronic heart diseases and mortality worldwide. Hypertension (HTN) is the utmost dominant risk factor for the evolution of several diseases. Herbal medicines, traditional medicinal herbs, and their extracts are widely utilized to treat and monitor HTN. Herbal components have been shown to help relax arteries and lower oxidative stress. The current study assesses the probable role of herbal plant extract Lagerstroemia speciosa (LS) in the LNAME induced HTN in rats. LNAME (50 mg/100 mL) in drinkable water was given to rats for five weeks. There was a significant upsurge in LNAME-treated hypertensive rats' blood pressure (BP). On treatment with LS, it ameliorates blood pressure. Further, LS also improved body weight, reduced heart weight, and heart hypertrophy. The NO/cGMP concentration was lowered along with a substantial upsurge in the level of glutathione and a decline in MDA level. The LS extract also reduced the inflammatory cytokine markers in the systemic circulation. In conclusion, thus, the extract of LS treatment can efficiently alleviate the BP, oxidative stress markers, and inflammation and improve NO/cGMP concentration in LNAME induced HTN in rats.
Competing Interests: The authors of this research affirm that they do not have any known competing economic interests or personal ties that could have given the appearance of influencing the work that is presented in this publication.
(Copyright © 2022 Mohammed S. Aleissa et al.)
Databáze: MEDLINE
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