Formation and fate of an engram in the lateral amygdala supporting a rewarding memory in mice.

Autor: Park A; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada., Jacob AD; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.; Department of Psychology, University of Toronto, Toronto, ON, M5G 1X8, Canada., Hsiang HL; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada., Frankland PW; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.; Department of Psychology, University of Toronto, Toronto, ON, M5G 1X8, Canada.; Department of Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada.; Child & Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, ON, M5G 1M1, Canada., Howland JG; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada. john.howland@usask.ca., Josselyn SA; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada. sheena.josselyn@sickkids.ca.; Department of Psychology, University of Toronto, Toronto, ON, M5G 1X8, Canada. sheena.josselyn@sickkids.ca.; Department of Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada. sheena.josselyn@sickkids.ca.
Jazyk: angličtina
Zdroj: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2023 Apr; Vol. 48 (5), pp. 724-733. Date of Electronic Publication: 2022 Oct 19.
DOI: 10.1038/s41386-022-01472-5
Abstrakt: Memories allow past experiences to guide future decision making and behavior. Sparse ensembles of neurons, known as engrams, are thought to store memories in the brain. Most previous research has focused on engrams supporting threatening or fearful memories where results show that neurons involved in a particular engram ("engram neurons") are both necessary and sufficient for memory expression. Far less is understood about engrams supporting appetitive or rewarding memories. As circumstances and environments are dynamic, the fate of a previously acquired engram with changing circumstances is unknown. Here we examined how engrams supporting a rewarding cue-cocaine memory are formed and whether this original engram is important in reinstatement of memory-guided behavior following extinction. Using a variety of techniques, we show that neurons in the lateral amygdala are allocated to an engram based on relative neuronal excitability at training. Furthermore, once allocated, these neurons become both necessary and sufficient for behavior consistent with recall of that rewarding memory. Allocated neurons are also critical for cocaine-primed reinstatement of memory-guided behavior following extinction. Moreover, artificial reactivation of initially allocated neurons supports reinstatement-like behavior following extinction even in the absence of cocaine-priming. Together, these findings suggest that cocaine priming after extinction reactivates the original engram, and that memory-guided reinstatement behavior does not occur in the absence of this reactivation. Although we focused on neurons in one brain region only, our findings that manipulations of lateral amygdala engram neurons alone were sufficient to impact memory-guided behavior indicate that the lateral amygdala is a critical hub region in what may be a larger brain-wide engram.
(© 2022. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.)
Databáze: MEDLINE
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