Prediction of incident atrial fibrillation with cardiac biomarkers and left atrial volumes.

Autor:	Lyngbakken MN; Department of Cardiology, Division of Medicine, Akershus University Hospital, Lorenskog, Norway magnus.lyngbakken@medisin.uio.no.; K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Rønningen PS; Department of Medical Research, Bærum sykehus, Gjettum, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Solberg MG; Department of Medical Research, Bærum sykehus, Gjettum, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Berge T; Department of Medical Research, Bærum sykehus, Gjettum, Norway., Brynildsen J; Department of Cardiology, Division of Medicine, Akershus University Hospital, Lorenskog, Norway., Aagaard EN; Department of Cardiology, Division of Medicine, Akershus University Hospital, Lorenskog, Norway.; K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Kvisvik B; Department of Cardiology, Division of Medicine, Akershus University Hospital, Lorenskog, Norway.; K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Røsjø H; K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Division of Research and Innovation, Akershus University Hospital, Lorenskog, Norway., Steine K; Department of Cardiology, Division of Medicine, Akershus University Hospital, Lorenskog, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Tveit A; Department of Medical Research, Bærum sykehus, Gjettum, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Omland T; Department of Cardiology, Division of Medicine, Akershus University Hospital, Lorenskog, Norway.; K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Jazyk:	angličtina
Zdroj:	Heart (British Cardiac Society) [Heart] 2023 Feb 14; Vol. 109 (5), pp. 356-363. Date of Electronic Publication: 2023 Feb 14.
DOI:	10.1136/heartjnl-2022-321608
Abstrakt:	Objective: Atrial fibrillation is a common arrhythmia associated with risk of stroke, heart failure and death. We aimed to elucidate the associations of cardiac biomarkers, echocardiographic left atrial volumetric indices and risk of prevalent and incident atrial fibrillation in the general population. Methods: We assessed cardiac troponin T (cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), growth differentiation factor 15 (GDF-15), maximum (LAVi max ) and minimum (LAVi min ) indexed left atrial volumes and left atrial emptying fraction (LAEF) in subjects born in 1950 participating in the prospective observational cohort, Akershus Cardiac Examination 1950 Study. The Cohorts for Heart and Ageing Research in Genomic Epidemiology for Atrial Fibrillation risk score and sex was used to adjust for residual risk of atrial fibrillation. Results: Out of 3487 subjects, 157 (4.5%) had prevalent and 123 (3.5%) had incident atrial fibrillation. Echocardiographic left atrial volumes and cardiac biomarkers associated with prevalent atrial fibrillation, but GDF-15 was non-significant in adjusted analysis. Incident atrial fibrillation was predicted by LAVi max (adjusted HR 1.51, 95% CI 1.30 to 1.75), LAVi min (adjusted HR 1.52, 95% CI 1.35 to 1.72), LAEF (adjusted HR 1.24, 95% CI 1.04 to 1.48) and NT-proBNP (adjusted HR 1.57, 95% CI 1.32 to 1.85). cTnT and NT-proBNP provided incremental prognostic information to left atrial volumes, but GDF-15 demonstrated no prognostic value for incident atrial fibrillation. Conclusions: In the general population, echocardiographic left atrial volumetric indices and NT-proBNP, but not cTnT and GDF-15, associate with prevalent atrial fibrillation and with risk of incident atrial fibrillation. cTnT and NT-proBNP provide incremental prognostic information to echocardiography. Competing Interests: Competing interests: TO has served on advisory boards for Abbott Diagnostics, Roche Diagnostics and Bayer, and has received research support from Abbott Diagnostics, Novartis, Roche Diagnostics, Singulex and SomaLogic via Akershus University Hospital, and speaker’s or consulting honoraria from Roche Diagnostics, Siemens Healthineers and CardioNor. TB has received speaker fees from Bayer, Boehringer Ingelheim, BMS and Pfizer (non-related to the submitted work). All other authors have no competing interests. (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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