High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons.

Autor:	Gooch HM; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Bluett T; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Perumal MB; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Vo HD; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Fletcher LN; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Papacostas J; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Jeffree RL; Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., Wood M; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Colditz MJ; Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., McMillen J; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Tsahtsarlis T; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Amato D; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Campbell R; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Gillinder L; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Williams SR; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: srw@uq.edu.au.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2022 Oct 18; Vol. 41 (3), pp. 111500.
DOI:	10.1016/j.celrep.2022.111500
Abstrakt:	Dendritic spikes function as cardinal components of rodent neocortical circuit computations. Recently, the biophysical properties of human pyramidal neurons (PNs) have been reported to be divergent, raising the question of whether dendritic spikes have homologous roles in the human neocortex. To directly address this, we made electrical recordings from the soma and apical dendrites of human and rat layer 2/3 PNs of the temporal cortex. In both species, dendritic excitatory input led to the initiation of sodium-channel-mediated dendritic spikes. Dendritic sodium spikes could be generated across a wide input range, exhibited a similar frequency range of activation, and forward-propagated with high-fidelity to implement stereotyped computations in human and rat PNs. However, the physical expansion and complexification of the apical dendritic trees of human PNs allowed the enriched expression of dendritic spike generation. The computational capacity of human PNs is therefore enhanced by the widespread implementation of a conserved dendritic integration mechanism. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu