John squire and endothelial glycocalyx structure: an unfinished story.

Autor: Arkill KP; School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK. kenton.arkill@nottingham.ac.uk., Michel CC; Department of Bioengineering, Imperial College London, London, UK. c.c.michel@imperial.ac.uk., Rider EVM; School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK., Wood EA; School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK., Small MO; School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK., Brown JLE; School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK., Kinnaird AL; School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK.
Jazyk: angličtina
Zdroj: Journal of muscle research and cell motility [J Muscle Res Cell Motil] 2023 Sep; Vol. 44 (3), pp. 217-223. Date of Electronic Publication: 2022 Oct 19.
DOI: 10.1007/s10974-022-09629-x
Abstrakt: John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding of endothelial glycocalyx structure and composition predicting 6 glycosaminoglycans fibres per syndecan core protein, only achieved in the endothelium by dimerization.
(© 2022. The Author(s).)
Databáze: MEDLINE
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