Evaluation of tooth eruption rate of incisor teeth in rats with estrogen deficiency.

Autor: Madalena IR; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida Do Café S/N, Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil., Marañón-Vásquez GA; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Cidade Universitária, Rua Prof. Rodolpho Paulo Rocco 325, Rio de Janeiro, RJ, 21941-617, Brazil., Omori MA; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida Do Café S/N, Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil., de Sousa ET; Department of Health Sciences and Pediatric Dentistry, Piracicaba Dental School, University of Campinas, Avenida Limeira 901, Areião, Piracicaba, SP, 13414-903, Brazil., da Silveira HA; Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University, Rua Humaitá, Araraquara, CentroSP, 168014801-903, Brazil., León JE; Department of Stomatology, Public Health and Forensic Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida Do Café S/N, Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil., Baratto-Filho F; School of Dentistry, University of the Joinville Region, Rua Paulo Malschitzki, s/n, Joinville, SC, 89219-710, Brazil., Alves SYF; Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida Do Café S/N, Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil., Stuani MBS; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida Do Café S/N, Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil., Nelson-Filho P; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida Do Café S/N, Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil., Kirschneck C; Department of Orthodontics, University Medical Centre of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany., Küchler EC; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida Do Café S/N, Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil. erikacalvano@gmail.com.; Department of Orthodontics, University Medical Centre of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany. erikacalvano@gmail.com.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2023 Jan; Vol. 27 (1), pp. 345-352. Date of Electronic Publication: 2022 Oct 19.
DOI: 10.1007/s00784-022-04738-w
Abstrakt: Objectives: To assess the influence of estrogen deficiency on tooth eruption rate (TER) and gene expression of estrogen receptor alpha and beta (ERα and ERβ) in the odontogenic region of teeth with continuous formation in a rat model.
Materials and Methods: Ovariectomies (OVX; n = 25) and sham surgeries (SHAM; n = 25) were performed in female Wistar rats when animals were 25 days old. The TER of the lower incisors, both in impeded (hyperfunction condition) and unimpeded (trimmed incisal edge-hypofunction condition) conditions, was evaluated using standardized digital photographs acquired every 48-72 h for 3 weeks (35th-53rd day of life), using a camera coupled to a stereomicroscope. Quantitative real-time PCR was performed to evaluate the relative gene expression of ERα and ERβ in the odontogenic region.
Results: The OVX group showed a significant reduction in TER when compared to the SHAM group, only in the impeded condition (p = 0.03). There was no statistically significant difference between the groups in ERα gene expression (p = 0.33). ERβ showed a significantly higher gene expression in the OVX group (p ≤ 0.05).
Conclusions: Estrogen deficiency decreases TER in teeth under impeded condition. Estrogen deficiency also increases ERβ gene expression in the odontogenic region of teeth with continuous formation.
Clinical Relevance: Hormonal disturbances affecting estrogen levels can cause alterations in dental formation and teeth eruption.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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