Bioactive Secondary Plant Metabolites from Euphorbia umbellata (PAX) BRUYNS (Euphorbiaceae).

Autor: Latansio de Oliveira T; Center for Biological and Health Sciences, UniCesumar, Desembargador Westphalen, 60, 84036-350, Paraná, Ponta Grossa, Brazil., Reder Custodio de Souza A; Department of Food Engineering, State University of Midwest, Alameda Élio Antonio Dalla Vecchia, 838, 85040-167, Paraná, Guarapuava, Brazil., Dias Fontana P; Department of Medical Pathology, Federal University of Paraná, 80060-900, Paraná, Curitiba, Brazil., Carvalho Carneiro M; Department of Immunology, University of São Paulo, Prof. Lineu Prestes Avenue, 05508-000, São Paulo, Brazil., Beltrame FL; Department of Pharmaceutical Science, State University of Ponta Grossa, Avenue General Carlos Cavalcanti, 4748, 84030-900, Paraná, Ponta Grossa, Brazil., de Messias Reason IJ; Department of Pharmaceutical Science, State University of Ponta Grossa, Avenue General Carlos Cavalcanti, 4748, 84030-900, Paraná, Ponta Grossa, Brazil., Bavia L; Department of Cell Biology, Federal University of Paraná, Avenida Coronel Francisco H. dos Santos, 100, 19031, 81531-980, Paraná, Curitiba, Brazil.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2022 Dec; Vol. 19 (12), pp. e202200568. Date of Electronic Publication: 2022 Nov 15.
DOI: 10.1002/cbdv.202200568
Abstrakt: The species Euphorbia umbellata has been used to treat inflammatory diseases, cancer, and ulcers. Biological activities reported in the literature, including antiproliferative, cytotoxic and anti-inflammatory, are attributed to the chemical constituents present in its composition as terpenes and polyphenolic compounds. The most recurrently verified metabolites in the Euphorbiaceae family plant species are terpenes, of which euphol is a major constituent with broadly reported cytotoxic, antinociceptive and anti-inflammatory effects; it frequently appears in various extracts obtained from the plant. Euphol has a documented inhibitory effect on neutrophil chemotaxis and can modulate the complement system. Since complement system activation is intimately intertwined with autoimmune and inflammatory diseases, tumor growth promotion and metastasis, plant metabolites from Euphorbia umbellata might influence the outcomes of inflammatory processes. We believe that this is the first review presenting the current knowledge on Euphorbia umbellata secondary metabolites and their biological activities.
(© 2022 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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