Role of Vitamin D Deficiency in Increased Susceptibility to Respiratory Infections Among Children: A Systematic Review.

Autor:	Raju A; Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Luthra G; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Shahbaz M; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Almatooq H; Dermatology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Foucambert P; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Esbrand FD; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Zafar S; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Panthangi V; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Cyril Kurupp AR; Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Khan S; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Sep 15; Vol. 14 (9), pp. e29205. Date of Electronic Publication: 2022 Sep 15 (Print Publication: 2022).
DOI:	10.7759/cureus.29205
Abstrakt:	Vitamin D has several roles in the immune system besides its effects on bone metabolism. Acute respiratory infections are common infections in children. Severe lower respiratory tract infections (LRTIs) even cause death in children, especially in those less than five years of age. Our study aims to examine whether children with vitamin D deficiency are susceptible to respiratory infections and to study the association between vitamin D deficiency and the severity of respiratory infections. We comprehensively searched research articles in PubMed, ScienceDirect, and Cochrane library databases. The main keywords were vitamin D deficiency, respiratory infections, and children. We used Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines to conduct this systematic review. The initial search showed 16,120 papers. A meticulous screening of research articles using the eligibility criteria and quality appraisal tools was done. Finally, 10 research articles qualified for this systematic review, including eight case-control studies, one randomized controlled trial (RCT), and one cohort study. Seven of 10 research studies reviewed found that children with low vitamin D levels are susceptible to respiratory infections. Five studies discussed the severity of respiratory infections and low vitamin D levels. This systematic review concluded that children with low vitamin D levels are prone to developing respiratory infections. But we could not find a conclusive association between the severity of respiratory infections and low vitamin D levels. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Raju et al.)
Databáze:	MEDLINE
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