Characteristics of Corneal Endothelium in Axenfeld Rieger Spectrum.

Autor:	Achanta DSR; Institute for Rare Eye Diseases and Ocular Genetics, L V Prasad Eye Institute, Hyderabad, India.; Jasti V Ramanamma Children's Eye Care Center, L V Prasad Eye Institute, Hyderabad, India., Chaurasia S; Institute for Rare Eye Diseases and Ocular Genetics, L V Prasad Eye Institute, Hyderabad, India.; Jasti V Ramanamma Children's Eye Care Center, L V Prasad Eye Institute, Hyderabad, India.; The Cornea Institute, L V Prasad Eye Institute, Hyderabad, India., Mohamed A; Institute for Rare Eye Diseases and Ocular Genetics, L V Prasad Eye Institute, Hyderabad, India.; Ophthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India; and., Barur SR; The Cornea Institute, L V Prasad Eye Institute, Hyderabad, India., Ramappa M; Institute for Rare Eye Diseases and Ocular Genetics, L V Prasad Eye Institute, Hyderabad, India.; Jasti V Ramanamma Children's Eye Care Center, L V Prasad Eye Institute, Hyderabad, India.; The Cornea Institute, L V Prasad Eye Institute, Hyderabad, India., Edward DP; Department of Ophthalmology and Visual Sciences and Pathology, University of Illinois College of Medicine, Chicago, IL.
Jazyk:	angličtina
Zdroj:	Cornea [Cornea] 2023 Oct 01; Vol. 42 (10), pp. 1216-1220. Date of Electronic Publication: 2022 Oct 17.
DOI:	10.1097/ICO.0000000000003163
Abstrakt:	Purpose: The purpose of this study was to compare the corneal endothelial characteristics in Axenfeld anomaly (AXA), Rieger anomaly (RGA), and Axenfeld-Rieger anomaly/syndrome with age-matched healthy controls. Methods: This is a retrospective, comparative case-control study of 52 eyes of 30 patients with AXA/RGA and AXA/S and 36 controls. Results: Median age at endothelial imaging was 21.5 years (interquartile range, 13.8-33.3 years). In the study group, the mean endothelial cell density (ECD) was 2112.4 ± 78.5 cells/mm 2 , the mean cell area (MCA) was 526.9 ± 28.5 μm 2 , and the coefficient of variation of cell size was 41.2 ± 1.8%. The ECD was significantly (all, P < 0.0001) lower than controls, while MCA ( P < 0.0001), SD of cell size ( P < 0.0001), and maximum cell area ( P = 0.0007) were significantly higher than controls. Four eyes of 3 patients had guttae on slitlamp evaluation and endothelial imaging. There were no differences in the corneal endothelial characteristics among the clinical subtypes. Conclusions: Patients with AXA, RGA, and Axenfeld-Rieger anomaly/syndrome have lower ECD and increased MCA compared with normal eyes. The reduced ECD associated with inherent anterior segment alterations can predispose to the risk of postcataract surgery endothelial decompensation in these eyes. The association of guttae in some eyes needs further investigational studies. Competing Interests: Conflicts of interest statement: The authors have no conflicts of interest to disclose. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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