The influence of advanced age and obesity on pregnancy course and outcome in patients with diabetes mellitus.

Autor:	Bapayeva G; Clinical Academic Department of Women's Health, Corporate Fund 'University Medical Centre', Nur-Sultan, Kazakhstan., Terzic S; Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan., Dotlic J; Clinic of Obstetrics and Gynaecology, Clinical Centre of Serbia, Belgrade, Serbia.; School of Medicine, University of Belgrade, Belgrade, Serbia., Togyzbayeva K; Clinical Academic Department of Women's Health, Corporate Fund 'University Medical Centre', Nur-Sultan, Kazakhstan., Bugibaeva U; Clinical Academic Department of Women's Health, Corporate Fund 'University Medical Centre', Nur-Sultan, Kazakhstan., Mustafinova M; Clinical Academic Department of Women's Health, Corporate Fund 'University Medical Centre', Nur-Sultan, Kazakhstan., Alisheva A; Clinical Academic Department of Women's Health, Corporate Fund 'University Medical Centre', Nur-Sultan, Kazakhstan., Karaman E; Department of Obstetrics and Gynaecology, Faculty of Medicine, Van Yüzüncü Yıl University, Van, Turkey., Terzic M; Clinical Academic Department of Women's Health, Corporate Fund 'University Medical Centre', Nur-Sultan, Kazakhstan.; Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan.; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Laganà AS; Unit of Gynecologic Oncology, ARNAS 'Civico - Di Cristina - Benfratelli', Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.
Jazyk:	angličtina
Zdroj:	Przeglad menopauzalny = Menopause review [Prz Menopauzalny] 2022 Sep; Vol. 21 (3), pp. 170-179. Date of Electronic Publication: 2022 May 18.
DOI:	10.5114/pm.2022.116351
Abstrakt:	Introduction: Older women are at greater risk of suffering from a series of comorbidities such as obesity, diabetes, and hypertension that could negatively affect pregnancy course and outcomes. This study aims to investigate the impact of maternal age and pre-pregnancy body mass index (BMI) on pregnancy outcomes of women with diabetes mellitus (DM). Material and Methods: The study included 323 diabetic pregnant women. All complications throughout pregnancy and the early neonatal period were noted. The women were divided into groups according to age decade and BMI. Results: 84.8% of women reported pregnancy complications, with a higher prevalence in obese women ( p = 0.003). However, most children had a good outcome with few early neonatal complications (36.85%). Old and obese women with DM often showed complications, and their newborns had higher birth weight ( p = 0.003) and more neonatal complications ( p = 0.041). Maternal BMI ( p = 0.016; OR = 1.064), but not age ( p = 0.801), was found to be a significant predictor of pregnancy complications. Conclusions: Pregnant women with DM should be considered as high-risk patients. Advanced age and increased BMI prior to pregnancy are risk factors for pregnancy complications. Maternal obesity is the most important predictor of pregnancy complications in women with DM. Pregnancy outcome can be good for both mothers and children with a timely and adequate approach. Competing Interests: The authors report no conflict of interest. (Copyright © 2022 Termedia.)
Databáze:	MEDLINE
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