Catalytic Biosensors Operating under Quasi-Equilibrium Conditions for Mitigating the Changes in Substrate Diffusion.
| Autor: | Muhs A; Analytical Chemistry-Center for Electrochemical Sciences, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstrasse 150, 44780, Bochum, Germany., Bobrowski T; Analytical Chemistry-Center for Electrochemical Sciences, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstrasse 150, 44780, Bochum, Germany., Lielpētere A; Analytical Chemistry-Center for Electrochemical Sciences, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstrasse 150, 44780, Bochum, Germany., Schuhmann W; Analytical Chemistry-Center for Electrochemical Sciences, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstrasse 150, 44780, Bochum, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Dec 23; Vol. 61 (52), pp. e202211559. Date of Electronic Publication: 2022 Nov 23. |
| DOI: | 10.1002/anie.202211559 |
| Abstrakt: | Despite the success of continuous glucose measuring systems operating through the skin for about 14 days, long-term implantable biosensors are facing challenges caused by the foreign-body reaction. We present a conceptually new strategy using catalytic enzyme-based biosensors based on a measuring sequence leading to minimum disturbance of the substrate equilibrium concentration by controlling the sensor between "on" and "off" state combined with short potentiometric data acquisition. It is required that the enzyme activity can be completely switched off and no parasitic side reactions allow substrate turnover. This is achieved by using an O (© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.) |
| Databáze: | MEDLINE |
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