Urinary phthalate metabolite concentrations and hot flash outcomes: Longitudinal associations in the Midlife Women's Health Study.

Autor: Babadi RS; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA., Williams PL; Departments of Biostatistics and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA., Li Z; Roy J. Carver Biotechnology Center, University of Illinois, Urbana, USA., Smith RL; Department of Pathobiology, Institute for Genomic Biology, and Carle Illinois College of Medicine, University of Illinois, Urbana, USA., Strakovsky RS; Department of Food Science and Human Nutrition and Institute for Integrative Toxicology, Michigan State University, East Lansing, USA., Hauser R; Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA., Flaws JA; Department of Comparative Biosciences and Institute for Genomic Biology, University of Illinois, Urbana, USA., James-Todd T; Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA. Electronic address: tjtodd@hsph.harvard.edu.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2023 Jan 01; Vol. 216 (Pt 2), pp. 114576. Date of Electronic Publication: 2022 Oct 14.
DOI: 10.1016/j.envres.2022.114576
Abstrakt: Midlife in women is an understudied time for environmental chemical exposures and menopausal outcomes. Recent cross-sectional research links phthalates with hot flashes, but little is known regarding such associations over time. Our objective was to estimate longitudinal associations between repeated measures of urinary phthalate metabolite concentrations and hot flash outcomes in midlife women. Using data from the Midlife Women's Health Study (MWHS), a prospective longitudinal study, we fit generalized linear mixed-effects models (GLMMs) and Cox proportional hazards regression models to repeated measures over a 4-year period. Recruitment occurred in Baltimore and surrounding counties, Maryland, USA between 2006 and 2015. Participants were premenopausal/perimenopausal women (n = 744) aged 45-54 years, who were not pregnant, not taking menopausal symptom medication or oral contraceptives, did not have hysterectomy/oophorectomy, and irrespective of hot flash experience. Baseline mean (SD) age was 48.4 (2.45), and 65% were premenopausal. Main outcome measures included adjusted odds ratios (ORs) for 4 self-reported hot flash outcomes (ever experienced, past 30 days experience, weekly/daily, and moderate/severe), and hazard ratios (HRs) for incident hot flashes. We observed mostly increased odds of certain hot flash outcomes with higher concentrations of metabolites of di (2-ethylhexyl) phthalate (DEHP), monoisobutyl phthalate (MiBP), and a molar summary measure of plasticizer phthalate metabolites (DEHP metabolites, mono-(3-carboxypropyl) phthalate (MCPP), monobenzyl phthalate (MBzP)). Some associations between exposures and outcomes indicated decreased odds. In conclusion, phthalate metabolites were associated with certain hot flash outcomes in midlife women. Midlife may be a sensitive period for higher phthalate metabolite concentrations with respect to menopausal symptoms.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Published by Elsevier Inc.)
Databáze: MEDLINE
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