Exergame and/or conventional training-induced neuroplasticity and cognitive improvement by engaging epigenetic and inflammatory modulation in elderly women: A randomized clinical trial.

Autor: Henrique PPB; Programa de Pós-Graduação em Envelhecimento Humano, Instituto de Saúde, Universidade de Passo Fundo, Passo Fundo, Brazil. Electronic address: patriciabazzanello@hotmail.com., Perez FMP; Programa de Pós-Graduação em Envelhecimento Humano, Instituto de Saúde, Universidade de Passo Fundo, Passo Fundo, Brazil., Dorneles G; Laboratório de Imunologia Celular e Molecular, Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil., Peres A; Laboratório de Imunologia Celular e Molecular, Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil., Korb A; Universidade Regional Integrada do Alto Uruguai e das Missões - URI Campus de Erechim, Brazil., Elsner V; Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., De Marchi ACB; Programa de Pós-Graduação em Envelhecimento Humano, Instituto de Saúde, Universidade de Passo Fundo, Passo Fundo, Brazil; Programa de Pós-Graduação em Computação Aplicada, Instituto de Tecnologia, Universidade de Passo Fundo, Passo Fundo, Brazil.
Jazyk: angličtina
Zdroj: Physiology & behavior [Physiol Behav] 2023 Jan 01; Vol. 258, pp. 113996. Date of Electronic Publication: 2022 Oct 14.
DOI: 10.1016/j.physbeh.2022.113996
Abstrakt: Objective: To evaluate the acute and long-term impact of exergaming (EXE) and conventional therapy (CON) in the peripheral levels of brain-derived neurotrophic factor (BDNF), inflammatory markers (interleukin [IL]-1b, IL-6, IL-8, and tumor necrosis factor-alpha [TNF-α]) and epigenetic mechanisms (global histone H3 and H4 acetylation levels in mononuclear cells) of healthy elderly women. We also evaluated the effect of intervention on cognitive performance in these individuals.
Methods: Twenty-two elderly women were randomly assigned into two groups: EXE (n = 12) and CON (n = 10). Both interventions were performed twice a week for 6 weeks (12 sessions). Blood samples were obtained before intervention, after the first session, and 1 hour after the last session. Cognitive performance was evaluated before and after intervention.
Results: Both EXE and CON interventions ameliorated cognitive performance, improved inflammatory profile, enhanced BDNF levels, and induced histone H4 and H3 hyperacetylation status in elderly women.
Conclusion: Our study demonstrated that the proposed interventions can be considered important strategies capable of promoting cognitive improvement in healthy elderly women. The acetylation status of histones and inflammatory cytokines are possible molecular mechanisms that mediate this beneficial response, being distinctly modulated by acute and long-term exposure.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
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