Chitosan/hyaluronic acid polyanion bilayer applied from carbon acid as an advanced coating with intelligent antimicrobial properties for improved biological prosthetic heart valves.

Autor: Chaschin IS; Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova, Moscow 119991, Russian Federation; Bakulev Scientific Center for Cardiovascular Surgery, 135 Rublevskoe Sh., Moscow 121552, Russian Federation. Electronic address: chaschin@polly.phys.msu.ru., Sinolits MA; Lomonosov Moscow State University, Chemistry Department, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Badun GA; Lomonosov Moscow State University, Chemistry Department, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Chernysheva MG; Lomonosov Moscow State University, Chemistry Department, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation., Anuchina NM; Bakulev Scientific Center for Cardiovascular Surgery, 135 Rublevskoe Sh., Moscow 121552, Russian Federation., Krasheninnikov SV; National Research Center 'Kurchatov Institute', Akademika Kurchatova pl., Moscow 123182, Russia., Khugaev GA; Bakulev Scientific Center for Cardiovascular Surgery, 135 Rublevskoe Sh., Moscow 121552, Russian Federation., Petlenko AA; Bakulev Scientific Center for Cardiovascular Surgery, 135 Rublevskoe Sh., Moscow 121552, Russian Federation., Britikov DV; Bakulev Scientific Center for Cardiovascular Surgery, 135 Rublevskoe Sh., Moscow 121552, Russian Federation., Zubko AV; Bakulev Scientific Center for Cardiovascular Surgery, 135 Rublevskoe Sh., Moscow 121552, Russian Federation., Kurilov AD; Bakulev Scientific Center for Cardiovascular Surgery, 135 Rublevskoe Sh., Moscow 121552, Russian Federation., Dreger EI; Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova, Moscow 119991, Russian Federation., Bakuleva NP; Bakulev Scientific Center for Cardiovascular Surgery, 135 Rublevskoe Sh., Moscow 121552, Russian Federation.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2022 Dec 01; Vol. 222 (Pt B), pp. 2761-2774. Date of Electronic Publication: 2022 Oct 14.
DOI: 10.1016/j.ijbiomac.2022.10.056
Abstrakt: The tightly bonded shielding coating on biomatrix significantly enhances the functionality of medical devices, bioprostheses in particular. In our work we have obtained a polyelectrolyte coating on a biomatrix by sequentially depositing chitosan and hyaluronic acid (HA) from solutions in carbonic acid under pressure. This approach makes it possible to obtain hybrid biomatrix with a firmly bonded polymer screen due to the electrostatic bonding of polyions. High-precision analysis using a tritium label shows a 3-fold increase in quantity of HA in carbonic acid under pressure compared to the conventional method. The presence of the chitosan layer increases the HA adsorption by 15-20 % due to electrostatic interaction of differently charged polymers. Antimicrobial results show the possibility of implementing an induced antimicrobial response, due to the lysis of the upper layer of the coating (HA) and the release of antimicrobial agents in the case of growth of pathogens on the bioprosthesis.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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