Cardiac innervations in diabetes mellitus-Anatomical evidence of neuropathy.

Autor: Filipović N; Department of Anatomy, Histology and Embryology, Laboratory for Experimental Neurocardiology, University of Split School of Medicine, Split, Croatia., Marinović Guić M; Department of Diagnostic and Interventional Radiology, University Hospital of Split, Split, Croatia.; University Department of Health Studies, University of Split, Split, Croatia., Košta V; Department of Neurology, University Hospital of Split, Split, Croatia., Vukojević K; Department of Anatomy, Histology and Embryology, Laboratory for Experimental Neurocardiology, University of Split School of Medicine, Split, Croatia.
Jazyk: angličtina
Zdroj: Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2023 Sep; Vol. 306 (9), pp. 2345-2365. Date of Electronic Publication: 2022 Oct 17.
DOI: 10.1002/ar.25090
Abstrakt: The extensive innervations of the heart include a complex network of sympathetic, parasympathetic, and sensory nerves connected in loops that serve to regulate cardiac output. Metabolic dysfunction in diabetes affects many different organ systems, including the cardiovascular system; it causes cardiac arrhythmias, silent myocardial ischemia, and sudden cardiac death, among others. These conditions are associated with damage to the nerves that innervate the heart, cardiac autonomic neuropathy (CAN), which is caused by various pathophysiological mechanisms. In this review, the main facts about the anatomy of cardiac innervations and the current knowledge of CAN, its pathophysiological mechanisms, and its diagnostic approach are discussed. In addition, anatomical evidence for CAN from human and animal studies has been summarized.
(© 2022 American Association for Anatomy.)
Databáze: MEDLINE
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