Dermoscopy of haemosiderotic/aneurysmal dermatofibroma: A morphological study of 110 cases.

Autor: Zaballos P; Dermatology Department, Hospital Sant Pau i Santa Tecla, Tarragona, Spain., Álvarez-Salafranca M; Dermatology Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain., Llambrich À; Dermatology Department, Hospital Universitari Son Llatzer, Palma de Mallorca, Spain., Malvehy J; Dermatology Department, Hospital Clínic, Barcelona, Spain., Taberner R; Dermatology Department, Hospital Universitari Son Llatzer, Palma de Mallorca, Spain., Medina C; Dermatology Department, Hospital Universitario de Gran Canaria 'Doctor Negrín', Gran Canaria, Spain., Argenziano G; Dermatology Unit, University of Campania, Naples, Italy., Thomas L; Department of Dermatology, Centre Hospitalier Lyon Sud, Lyon, France.; Lyon 1 University, Lyon, France.; Lyons Cancer Research Center UMR INSERM U1052 - CNRS5286 - UCBL1, Lyon, France., Pizarro Á; Dermatology Department, Clínica Dermatológica Internacional, Madrid, Spain., Del Pozo LJ; Dermatology Department, Hospital Universitari Son Espases, Palma de Mallorca, Spain., Avilés JA; Dermatology Department, Hospital Universitario Gregorio Marañón, Madrid, Spain., Martin JM; Dermatology Department, Hospital Clínico Universitario, Valencia, Spain., Karaarslan I; Dermatology Department, Medical University of Ege, Izmir, Turkey., Guionnet N; Pathology Department, Hospital de Sant Pau I Santa Tecla, Tarragona, Spain., Bañuls J; Dermatology Department, Hospital General Universitario de Alicante, ISABIAL, Alicante, Spain.
Jazyk: angličtina
Zdroj: Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2023 Feb; Vol. 37 (2), pp. 317-327. Date of Electronic Publication: 2022 Nov 08.
DOI: 10.1111/jdv.18664
Abstrakt: Background: Haemosiderotic and aneurysmal dermatofibromas are uncommon and frequently misdiagnosed lesions, which can be considered as different histopathological stages of the same tumour. A dermoscopic diagnosis testing accuracy has not been performed for these tumours to date.
Objectives: To determine the diagnostic significance of dermoscopic structures and patterns associated with haemosiderotic/ aneurysmal dermatofibromas in a large series.
Methods: Dermoscopic images of histopathologically proven cases of 110 haemosiderotic/ aneurysmal dermatofibromas and 501 other tumours were collected. The frequency, sensitivity, specificity, positive predictive value and negative predictive value of the dermoscopic structures and patterns associated with these lesions were calculated.
Results: Haemosiderotic/ aneurysmal dermatofibromas are mostly symmetric lesions (86.5%), and a prominent homogeneous area was present in 100% of them. The presence of vascular structures was very common (86.4%), and dotted vessels were predominant (58.2%). Shiny white structures were seen in 85.5% of lesions, while a peripheral delicate pigment network was present in 69.1%. The most significant pattern was the one composed of a prominent homogeneous area and peripheral delicate pigment network, which showed a specificity of 100% with a relatively good sensitivity (69.1%). All the patterns containing a peripheral delicate pigment network showed very good specificities, positive predictive values and negative predictive values. Those patterns without a peripheral delicate pigment network showed the highest sensitivities, but they showed a significant overlap with other tumours, mainly with melanoma.
Conclusions: Dermoscopy is helpful in improving the diagnostic accuracy of haemosiderotic/ aneurysmal dermatofibromas. However, there is a considerable dermoscopic overlap between these tumours and melanoma, specifically when the peripheral delicate pigment network is absent.
(© 2022 European Academy of Dermatology and Venereology.)
Databáze: MEDLINE
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