Reducing Sedentary Time and Whole-Body Insulin Sensitivity in Metabolic Syndrome: A 6-Month Randomized Controlled Trial.

Autor:	Sjöros T; Turku PET Centre, University of Turku and Turku University Hospital, Turku, FINLAND., Laine S; Turku PET Centre, University of Turku and Turku University Hospital, Turku, FINLAND., Garthwaite T; Turku PET Centre, University of Turku and Turku University Hospital, Turku, FINLAND., Vähä-Ypyä H; The UKK Institute for Health Promotion Research, Tampere, FINLAND., Löyttyniemi E; Department of Biostatistics, University of Turku, Turku, FINLAND., Koivumäki M; Turku PET Centre, University of Turku and Turku University Hospital, Turku, FINLAND., Houttu N; Institute of Biomedicine, University of Turku, Turku, FINLAND., Laitinen K; Institute of Biomedicine, University of Turku, Turku, FINLAND., Kalliokoski KK; Turku PET Centre, University of Turku and Turku University Hospital, Turku, FINLAND., Sievänen H; The UKK Institute for Health Promotion Research, Tampere, FINLAND., Vasankari T, Knuuti J; Turku PET Centre, University of Turku and Turku University Hospital, Turku, FINLAND., Heinonen IHA
Jazyk:	angličtina
Zdroj:	Medicine and science in sports and exercise [Med Sci Sports Exerc] 2023 Mar 01; Vol. 55 (3), pp. 342-353. Date of Electronic Publication: 2022 Oct 13.
DOI:	10.1249/MSS.0000000000003054
Abstrakt:	Purpose: This study aimed to investigate whether a reduction in daily sedentary behavior (SB) improves insulin sensitivity in adults with metabolic syndrome in 6 months, without adding intentional exercise training. Methods: Sixty-four sedentary inactive middle-age adults with overweight and metabolic syndrome (mean (SD) age, 58 (7) yr; mean (SD) body mass index, 31.6 (4.3) kg·m -2 ; 27 men) were randomized into intervention and control groups. The 6-month individualized behavioral intervention supported by an interactive accelerometer and a mobile application aimed at reducing daily SB by 1 h compared with baseline. Insulin sensitivity by hyperinsulinemic euglycemic clamp, body composition by air displacement plethysmography, and fasting blood samples were analyzed before and after the intervention. SB and physical activity were measured with hip-worn accelerometers throughout the intervention. Results: SB decreased by 40 (95% confidence interval, 17-65) min·d -1 , and moderate-to-vigorous physical activity increased by 20 (95% confidence interval, 11-28) min·d -1 on average in the intervention group with no significant changes in these outcomes in the control group. After 6 months, fasting plasma insulin decreased (~1 mU·L -1 ) in the intervention group compared with the control group (time-group, P = 0.0081), but insulin sensitivity did not change in either group. The changes in body mass or adiposity did not differ between groups. Among all participants, the changes in SB and body mass correlated inversely with the change in insulin sensitivity ( r = -0.31, -0.44; P = 0.025, 0.0005, respectively). Conclusions: An intervention aimed at reducing daily SB resulted in slightly decreased fasting insulin, but had no effects on insulin sensitivity or body adiposity. However, as the change in insulin sensitivity associated with the changes in SB and body mass, multifaceted interventions targeting to weight loss are likely to be beneficial in improving whole-body insulin sensitivity. (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine.)
Databáze:	MEDLINE
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