Using a combination of midazolam and butorphanol is a safe and effective reversible field sedation protocol for Weddell seal (Leptonychotes weddellii) pups.

Autor: Whoriskey S; The Marine Mammal Center, Sausalito, California, USA., Pearson LE; California Polytechnic State University, San Luis Obispo, California, USA., Harris HS; The Marine Mammal Center, Sausalito, California, USA.; California Polytechnic State University, San Luis Obispo, California, USA., Whitmer ER; The Marine Mammal Center, Sausalito, California, USA., Liwanag HEM; California Polytechnic State University, San Luis Obispo, California, USA., Brodie E; The Marine Mammal Center, Sausalito, California, USA., Johnson S; The Marine Mammal Center, Sausalito, California, USA.; Sea Change Health, Sunnyvale, California, USA.
Jazyk: angličtina
Zdroj: The Veterinary record [Vet Rec] 2022 Dec; Vol. 191 (11), pp. e2238. Date of Electronic Publication: 2022 Oct 17.
DOI: 10.1002/vetr.2238
Abstrakt: Background: Weddell seals (Leptonychotes weddellii) are a well-studied species of phocid with an apparent sensitivity to immobilising agents. Mortality as high as 31% has been reported during field immobilisation. This study investigated the use of a benzodiazepine in combination with an opioid agonist/antagonist for sedation in Weddell seal pups as part of a physiological study.
Methods: During the 2017 and 2019 Antarctic pupping seasons, 18 Weddell seal pups were sedated by intramuscular administration of a combination of midazolam and butorphanol or intravenous midazolam alone. Individuals were sedated at 1, 3, 5 and 7 weeks of age. Naltrexone and flumazenil were used to reverse sedation. The combination was 100% effective in providing appropriate sedation for the intended procedures.
Results: Analyses were performed to investigate relationships between dose administered, age, individual reactions, adverse effects and changes in dive physiology. Transient apnoea (10-60 seconds) was the most frequently observed adverse effect. No sedation-associated morbidity or mortality occurred.
Limitations: The sample size is small and there is no pharmacokinetic information for either sedative or reversal in phocid species.
Conclusions: The combination of midazolam (0.2-0.3 mg/kg) and butorphanol (0.1-0.2 mg/kg) provided safe and effective sedation, with reversible effects, in Weddell seal pups.
(© 2022 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association.)
Databáze: MEDLINE
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