Correlation between Ubiquitin E3 Ligases ( SIAH s) and Heat Shock Protein 90 in Breast Cancer Patients.

Autor:	Sabour Takanlou L; Deparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey., Cecener G; Deparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey., Sabour Takanlou M; Deparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey., Ozturk Nazlioglu H; Department of Medical Pathology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey., Tezcan Unlu H; Deparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey., Isik O; Department of General Surgey, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey., Egeli U; Deparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey., Tunca B; Deparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey., Cubukcu E; Department of Medical Oncology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey., Tolunay S; Department of Medical Pathology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey., Gokgoz MS; Department of General Surgey, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Jazyk:	angličtina
Zdroj:	Iranian journal of public health [Iran J Public Health] 2022 Aug; Vol. 51 (8), pp. 1836-1846.
DOI:	10.18502/ijph.v51i8.10270
Abstrakt:	Background: Breast cancer is a heterogeneous disease and differences in the expression levels of the ER, PR, and HER2 the triplet of established biomarkers used for clinical decision-making have been reported among breast cancer patients. Furthermore, resistance to anti-estrogen and anti-HER2 therapies emerges in a considerable rate of breast cancer patients, and novel drug therapies are required. Several anomalous signaling pathways have been known in breast cancer have been known; heat shock protein 90 (HSP90) is one of the most plenty proteins in breast cells. The family of ubiquitin ligases such as SIAH1 and SIAH2 is known to specifically target misfolded proteins to the proteasome; also, they have been illustrated to play a role in RAS signaling and as an essential downstream signaling component required for EGFR/HER2 in breast cancer. Methods: The expression of SIAH2, HSP90 , and HER2 was assessed by quantitative Real-Time PCR in 85 invasive ductal carcinoma breast tumor samples at Uludag University Hospital in Turkey during the years 2018-2019, and its association with the clinicopathologic variables of patients was evaluated. Results: HSP90 , SIAH1 , and SIAH2 were significantly ( P =0.0271, P =0.022, and P =0.0311) upregulated tumor tissue of patients with breast cancer. Moreover, this study observed a significant association between the high expression of SIAH2 / HSP90 with ER status, high expression of HSP90 with Recurrence/Metastasis, and high expression of SIAH2 with Ki-67 proliferation index. Conclusion: The HSP90 and SIAH2 expressions play a significant role in breast cancer development by combining the experimental and clinical data obtained from the literature. Competing Interests: Conflict of interest The authors declare no conflict of interest. (Copyright © 2022 Takanlou et al. Published by Tehran University of Medical Sciences.)
Databáze:	MEDLINE
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