Update in Cushing disease: What the neurosurgeon has to KNOW, on behalf of the EANS skull base section.

Autor:	Eulate-Beramendi S; Department of Neurosurgery, University Hospital of Navarre, Pamplona, Spain., Casajús A; Department of Neurosurgery, University Hospital of Navarre, Pamplona, Spain., Ollero L; Department of Endocrinology, University Hospital of Navarre, Pamplona, Spain., Niemann LK; Department of Endocrinology, National Institute of Health, Bethesda, MD, USA., Fernández-Miranda JC; Department of Neurosurgery, Stanford University Medical Center, USA., Bruneau M; Department of Neurosurgery, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium., Berhouma M; Neurosurgery Department, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France., Cavallo LM; Department of Neurosurgery, University of Naples Federico II, Naples, Italy., Cornelius JF; Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Daniel RT; Department of Neurosurgery, Department of Neuroscience, Centre Hospitalier Universitaire Vaudois, University Hospital, Lausanne, Switzerland., Froelich S; Department of Neurosurgery, Lariboisière Hospital, Université Paris Diderot, Paris, France., Jouanneau E; Neurosurgery Department, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France., Kasper E; Department of Neurosurgery, St Elizabeth's Medical Center, Brighton, Massachusetts, USA., Mazzatenta D; Department of Neurosurgery, Neurological Sciences Institut IRCCS, Bologna, Italy., Meling TR; Department of Neurosurgery, University Hospital of Geneva, Geneva, Switzerland., Messerer M; Department of Neurosurgery, Department of Neuroscience, Centre Hospitalier Universitaire Vaudois, University Hospital, Lausanne, Switzerland., Schroeder HWS; Department of Neurosurgery, University Medicine, Greifswald, Germany., Tatagiba M; Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany., Visocchi M; Department of Neurosurgery, Institute of Neurosurgery Catholic University of Rome, Italy., Voormolen EH; Department of Neurosurgery, University Medical Center, Utrecht, Netherlands., Zazpe I; Department of Neurosurgery, University Hospital of Navarre, Pamplona, Spain.
Jazyk:	angličtina
Zdroj:	Brain & spine [Brain Spine] 2022 Aug 07; Vol. 2, pp. 100917. Date of Electronic Publication: 2022 Aug 07 (Print Publication: 2022).
DOI:	10.1016/j.bas.2022.100917
Abstrakt:	Introduction: Cushing's disease is a state of chronic and excessive cortisol levels caused by a pituitary adenoma. Research Question: CD is a complex entity and often entails difficulties in its diagnosis and management. For that reason, there are still controversial points to that respect. The aim of this consensus paper of the skull base section of the EANS is to review the main aspects of the disease a neurosurgeon has to know and also to offer updated recommendations on the controversial aspects of its management. Material and Methods: PUBMED database was used to search the most pertinent articles published on the last 5 years related with the management of CD. A summary of literature evidence was proposed for discussion within the EANS skull base section and other international experts. Results: This article represents the consensual opinion of the task force regarding optimal management and surgical strategy in CD. Discussion and Conclusion: After discussion in the group several recommendations and suggestions were elaborated. Patients should be treated by an experienced multidisciplinary team. Accurate clinical, biochemical and radiological diagnosis is mandatory. The goal of treatment is the complete adenoma resection to achieve permanent remission. If this is not possible, the treatment aims to achieving eucortisolism. Radiation therapy is recommended to patients with CD when surgical options have been exhausted. All patients in remission should be tested all life-long. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors. Published by Elsevier B.V. on behalf of EUROSPINE, the Spine Society of Europe, EANS, the European Association of Neurosurgical Societies.)
Databáze:	MEDLINE
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