The association of patient age with postoperative morbidity and mortality following resection of intracranial tumors.

Autor:	Yang Y; Department of Neurosurgery, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland.; Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Zurich, Switzerland., Zeitlberger AM; Department of Neurosurgery, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland., Neidert MC; Department of Neurosurgery, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland.; Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Zurich, Switzerland., Staartjes VE; Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Zurich, Switzerland., Broggi M; Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.; Department of Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Zattra CM; Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Vasella F; Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Zurich, Switzerland., Velz J; Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Zurich, Switzerland., Bartek J Jr; Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.; Department of Clinical Neuroscience and Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark., Fletcher-Sandersjöö A; Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.; Department of Clinical Neuroscience and Medicine, Karolinska Institutet, Stockholm, Sweden., Förander P; Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.; Department of Clinical Neuroscience and Medicine, Karolinska Institutet, Stockholm, Sweden., Kalasauskas D; Department of Neurosurgery, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Renovanz M; Department of Neurosurgery, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Ringel F; Department of Neurosurgery, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Brawanski KR; Department of Neurosurgery, Medical University of Innsbruck, Innsbruck, Austria., Kerschbaumer J; Department of Neurosurgery, Medical University of Innsbruck, Innsbruck, Austria., Freyschlag CF; Department of Neurosurgery, Medical University of Innsbruck, Innsbruck, Austria., Jakola AS; Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden.; Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden., Sjåvik K; Department of Neurosurgery, University Hospital of North Norway, Tromsö, Norway., Solheim O; Department of Neurosurgery, St. Olavs University Hospital, Trondheim, Norway., Schatlo B; Department of Neurosurgery, Georg August University, University Medical Center, Göttingen, Germany., Sachkova A; Department of Neurosurgery, Georg August University, University Medical Center, Göttingen, Germany., Bock HC; Department of Neurosurgery, Georg August University, University Medical Center, Göttingen, Germany., Hussein A; Department of Neurosurgery, Georg August University, University Medical Center, Göttingen, Germany., Rohde V; Department of Neurosurgery, Georg August University, University Medical Center, Göttingen, Germany., Broekman MLD; Department of Neurosurgery, Haaglanden Medical Center, The Hague, the Netherlands.; Department of Neurosurgery, Leiden University Medical Center, Leiden, the Netherlands., Nogarede CO; Department of Neurosurgery, Haaglanden Medical Center, The Hague, the Netherlands.; Department of Neurosurgery, Leiden University Medical Center, Leiden, the Netherlands., Lemmens CMC; Department of Neurology, Haaglanden Medical Center, The Hague, the Netherlands., Kernbach JM; Department of Neurosurgery, Faculty of Medicine, RWTH Aachen University, Aachen, Germany., Neuloh G; Department of Neurosurgery, Faculty of Medicine, RWTH Aachen University, Aachen, Germany., Krayenbühl N; Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Zurich, Switzerland., Ferroli P; Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Regli L; Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Zurich, Switzerland., Bozinov O; Department of Neurosurgery, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland., Stienen MN; Department of Neurosurgery, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland.; Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Zurich, Switzerland.
Jazyk:	angličtina
Zdroj:	Brain & spine [Brain Spine] 2021 Oct 21; Vol. 1, pp. 100304. Date of Electronic Publication: 2021 Oct 21 (Print Publication: 2021).
DOI:	10.1016/j.bas.2021.100304
Abstrakt:	Introduction: The postoperative functional status of patients with intracranial tumors is influenced by patient-specific factors, including age. Research Question: This study aimed to elucidate the association between age and postoperative morbidity or mortality following the resection of brain tumors. Material and Methods: A multicenter database was retrospectively reviewed. Functional status was assessed before and 3-6 months after tumor resection by the Karnofsky Performance Scale (KPS). Uni- and multivariable linear regression were used to estimate the association of age with postoperative change in KPS. Logistic regression models for a ≥10-point decline in KPS or mortality were built for patients ≥75 years. Results: The total sample of 4864 patients had a mean age of 56.4 ​± ​14.4 years. The mean change in pre-to postoperative KPS was -1.43. For each 1-year increase in patient age, the adjusted change in postoperative KPS was -0.11 (95% CI -0.14 - - 0.07). In multivariable analysis, patients ≥75 years had an odds ratio of 1.51 to experience postoperative functional decline (95%CI 1.21-1.88) and an odds ratio of 2.04 to die (95%CI 1.33-3.13), compared to younger patients. Discussion: Patients with intracranial tumors treated surgically showed a minor decline in their postoperative functional status. Age was associated with this decline in function, but only to a small extent. Conclusion: Patients ≥75 years were more likely to experience a clinically meaningful decline in function and about two times as likely to die within the first 6 months after surgery, compared to younger patients. (© 2021 The Authors.)
Databáze:	MEDLINE
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