Pre COVID-19 molecular epidemiology of respiratory syncytial virus (RSV) among children in Bangladesh.

Autor:	Hossain ME; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh., Rahman MZ; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh., Islam MM; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh., Hoque AF; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh., Sumiya MK; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh., Begum MN; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh., Alam MM; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh., Uddin KMM; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh., Hassan MZ; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh., Rahman M; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh., Goswami DR; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh., Brooks WA; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.; Bloomberg School of Public, Department of International Health, Johns Hopkins University, United States.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2022 Oct; Vol. 8 (10), pp. e11043. Date of Electronic Publication: 2022 Oct 11.
DOI:	10.1016/j.heliyon.2022.e11043
Abstrakt:	Epidemiological data of specific respiratory pathogens from the pre-COVID-19 period are essential to determine the effects of the COVID-19 pandemic on other respiratory infections. In this study, we revealed the pre-COVID-19 molecular epidemiology of respiratory syncytial virus (RSV) among children in Bangladesh. We tested 3170 samples collected from 2008 to 2012 for a panel of respiratory viruses; RSV, human metapneumovirus (hMPV), human parainfluenza viruses (hPIV) 1, 2, 3, and adenovirus. Five hundred fifty-five samples (17.5 %) were positive for RSV, including 2.5% having co-infections with other viruses. Genotypic characterization of RSV showed that RSV-A (82%) contributed more acute respiratory infections than RSV-B (18%). Clinical features were similar with RSV-A and RSV-B infections. However, children with RSV-B were more likely to have upper respiratory infections (URI) (10% vs. 29%, p = 0.03). Among RSV-A cases, hospitalization was higher for ON1 cases (25%, ON1 vs. 8%, NA1, p = 0.04), whereas the recovery without a disability was higher among the NA1 cases (56%, ON1 vs. 88%, NA1, p = 0.02). The time to the most recent common ancestor (TMRCA) for RSV in Bangladesh was 1949 for RSV-A and 1944 for RSV-B. This study revealed the genotypic diversity and evolutionary relatedness of RSV strains in Bangladesh and provided pre-COVID molecular epidemiology data to understand better the COVID-19 impact on upcoming RSV epidemiology in Bangladesh. Competing Interests: The authors declare no conflict of interest. (© 2022 The Authors.)
Databáze:	MEDLINE
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