Efficacy of different salvage regimens in progressive unresectable pediatric low-grade glioma.

Autor: El-Hemaly A; Department of Pediatric Oncology, Children's Cancer Hospital Egypt 57357, Cairo 11617, Egypt.; Department of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo 11796, Egypt., Taha H; Department of Pathology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.; Department of Pathology, Children's Cancer Hospital Egypt 57357, Cairo 11617, Egypt., Refaat A; Department of Radiodiagnosis, National Cancer Institute, Cairo University, Cairo 11796, Egypt.; Department of Radiodiagnosis, Children's Cancer Hospital Egypt 57357, Cairo 11617, Egypt., Adel F; Department of Research, Children's Cancer Hospital Egypt 57357, Cairo 11617, Egypt., Elbeltagy M; Department of Neurosurgery, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11796, Egypt.; Department of Neurosurgery, Children's Cancer Hospital Egypt 57357, Cairo 11617, Egypt., Arafah O; Department of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Jazyk: angličtina
Zdroj: Oncology letters [Oncol Lett] 2022 Sep 26; Vol. 24 (5), pp. 407. Date of Electronic Publication: 2022 Sep 26 (Print Publication: 2022).
DOI: 10.3892/ol.2022.13527
Abstrakt: Multiple salvage chemotherapy regimens are used in progressive low-grade glioma (LGG), with no single regimen being more effective than any other. In the present study, different salvage therapies were compared with regard to the response rate, overall survival (OS) rate, event-free survival (EFS) rate and visual outcome in 70 patients with pediatric LGG. Age was found to significantly affect the EFS and OS rates (P<0.001). The visual outcome was the same between the three regimens. The 2-year EFS and OS rates of the vincristine/carboplatin, monthly carboplatin and weekly vinblastine regimens were 64.7 and 70.6%, 71.0 and 85.0%, and 56.0 and 62.7%, respectively (P=0.6 for EFS; P=0.56 for OS). Overall, the present study demonstrated that age had a significant impact on survival. The three salvage regimens used were equally effective with regard to the radiological response and visual outcome. However, further randomized controlled trials are required to detect the optimal salvage therapy.
Competing Interests: The authors declare that they have no competing interests.
(Copyright: © El-Hemaly et al.)
Databáze: MEDLINE
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