Hepatic Amyloidosis in a Chronically Entangled Grey Seal (Halichoerus grypus).

Autor: Barnett JEF; Cornwall Marine Pathology Team, Falmouth, Cornwall, UK. Electronic address: jamesbarnettvet@gmail.com., Gilbertson JA; National Amyloidosis Centre, UCL and Royal Free London NHS Foundation Trust, London, UK., Arrow N; British Divers Marine Life Rescue, Uckfield, East Sussex, UK., Gillmore JD; National Amyloidosis Centre, UCL and Royal Free London NHS Foundation Trust, London, UK., Hawkins PN; National Amyloidosis Centre, UCL and Royal Free London NHS Foundation Trust, London, UK., Larbalestier L; British Divers Marine Life Rescue, Uckfield, East Sussex, UK., Jarvis D; British Divers Marine Life Rescue, Uckfield, East Sussex, UK., Sayer S; Seal Research Trust, Hayle, Cornwall, UK., Wessels ME; Finn Pathologists, Weybread, Norfolk, UK.
Jazyk: angličtina
Zdroj: Journal of comparative pathology [J Comp Pathol] 2022 Nov; Vol. 199, pp. 1-7. Date of Electronic Publication: 2022 Oct 14.
DOI: 10.1016/j.jcpa.2022.09.003
Abstrakt: Grey seal (Halichoerus grypus) entrapment in fishing gear is well documented, consisting of two forms: peracute underwater entrapment and chronic entanglement. We now highlight a previously undescribed sequela to chronic entanglement in a female grey seal estimated to be at least 2 years of age. The animal was first observed in September 2018 on the coast of north Cornwall, southwest England, with a large encircling neck wound consistent with monofilament net entanglement. In April 2021, it was admitted for attempted rehabilitation but had to be euthanized after 9 days due to clinical deterioration despite treatment. At post-mortem examination, the seal was in poor nutritional state, the nose to flipper length was low for its estimated age and the liver was markedly enlarged, pale and friable in texture with evidence of recent and previous hepatic haemorrhage. Histopathology revealed hepatic amyloidosis and evidence of amyloid in one kidney and one adrenal gland. Proteomic analysis of microdissected amyloid from the liver indicated type AA amyloid. Chronic entanglement is the most plausible cause of AA amyloidosis in this animal, indicating that amyloidosis should be considered as a pathological sequela and welfare concern associated with chronic entanglement of grey seals.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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