Velocity vector comparison between vector flow imaging and computational fluid dynamics in the carotid bifurcation.

Autor: Poloni S; Department of Biomedical Engineering, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy., Bozzetto M; Department of Biomedical Engineering, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy., Du Y; Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen 518057, China., Aiani L; Centro Medico SME - Diagnostica per Immagini, Varese, Italy., Goddi A; Centro Medico SME - Diagnostica per Immagini, Varese, Italy., Fiorina I; Institute of Radiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Remuzzi A; Department of Management, Information and Production Engineering, University of Bergamo, Italy. Electronic address: andrea.remuzzi@unibg.it.
Jazyk: angličtina
Zdroj: Ultrasonics [Ultrasonics] 2023 Feb; Vol. 128, pp. 106860. Date of Electronic Publication: 2022 Oct 08.
DOI: 10.1016/j.ultras.2022.106860
Abstrakt: It has been largely documented that local hemodynamic conditions, characterized by low and oscillating wall shear stresses, play a key role in the initiation and progression of vascular atherosclerotic lesions. Thus, investigation of the flow field in the carotid bifurcation can lead to early identification of vulnerable plaques. In this scenario, the development of novel non-invasive imaging tools that can be used in routine clinical practice to identify disturbed and recirculating blood flow becomes crucial. In this context, Vector Flow Imaging is becoming a relevant tool as it provides an angle independent assessment of blood flow velocity and multidimensional flow vector visualization. The purpose of the present study was to validate, in several locations of the carotid bifurcation, the high-frame rate vector flow imaging (HiFR-VFI) technique by comparing with computational fluid dynamic simulations (CFD). In all eight carotid bifurcations, HiFR-VFI accurately detected regions of laminar flow as well as recirculation and unsteady flow areas. An accurate and statistically significant agreement was observed between velocity vectors obtained by HiFR-VFI and those computed by CFD, both for vector magnitude (R = 0.85) and direction (R = 0.74). Our study demonstrated that HiFR-VFI is a valid technique for rapid and advanced visual representation of velocity field in large arteries. Thus, it has a great potential in research-based clinical practice for the identification of flow recirculation, low and oscillating velocity gradients near vessel wall. The use of HiFR-VFI may provide a great improvement in the investigation of the role of local hemodynamics in vascular pathologies, as well in the assessment of the effect of pharmacological treatments.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: SP reports financial support was provided by Shenzhen Mindray Bio-medical Electronics Co., Ltd. AG reports a relationship with Shenzhen Mindray Bio-medical Electronics Co., Ltd., that includes: consulting or advisory. YD reports a relationship with Shenzhen Mindray Bio-medical Electronics Co., Ltd., that includes: employment.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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