Risk for bipolar spectrum disorders associated with positive urgency and orbitofrontal cortical grey matter volume.

Autor:	Carroll AL; Department of Psychology, Northwestern University, Evanston IL, United States. Electronic address: AnnCarroll2021@u.northwestern.edu., Damme KSF; Department of Psychology, Northwestern University, Evanston IL, United States; Institute for Innovation in Developmental Sciences, Chicago IL, United States., Alloy LB; Department of Psychology and Neuroscience, Temple University, Philadelphia PA, United States., Bart CP; Department of Psychology and Neuroscience, Temple University, Philadelphia PA, United States., Ng TH; Department of Psychology and Neuroscience, Temple University, Philadelphia PA, United States., Titone MK; Department of Psychology and Neuroscience, Temple University, Philadelphia PA, United States., Chein J; Department of Psychology and Neuroscience, Temple University, Philadelphia PA, United States., Cichocki AC; Department of Psychology, Northwestern University, Evanston IL, United States., Armstrong CC; Department of Psychology, Northwestern University, Evanston IL, United States., Nusslock R; Department of Psychology, Northwestern University, Evanston IL, United States; Institute for Policy Research, Northwestern University, Evanston IL, United States.
Jazyk:	angličtina
Zdroj:	NeuroImage. Clinical [Neuroimage Clin] 2022; Vol. 36, pp. 103225. Date of Electronic Publication: 2022 Oct 12.
DOI:	10.1016/j.nicl.2022.103225
Abstrakt:	Bipolar spectrum disorders (BSDs) are associated with reward hypersensitivity, impulsivity, and structural abnormalities within the brain's reward system. Using a behavioral high-risk study design based on reward sensitivity, this paper had two primary objectives: 1) investigate whether elevated positive urgency, the tendency to act rashly when experiencing extreme positive affect, is a risk for or correlate of BSDs, and 2) examine the nature of the relationship between positive urgency and grey matter volume in fronto-striatal reward regions, among individuals at differential risk for BSD. Young adults (ages 18-28) screened to be moderately reward sensitive (MReward; N = 42), highly reward sensitive (HReward; N = 48), or highly reward sensitive with a lifetime BSD (HReward + BSD; N = 32) completed a structural MRI scan and the positive urgency subscale of the UPPS-P scale. Positive urgency scores varied with BSD risk (MReward < HReward < HReward + BSD; ps≤0.05), and positive urgency interacted with BSD risk group in predicting lateral OFC volume (p <.001). Specifically, the MReward group showed a negative relationship between positive urgency and lateral OFC volume. By contrast, there was no relationship between positive urgency and lateral OFC grey matter volume among the HReward and HReward + BSD groups. The results suggest that heightened trait positive urgency is a pre-existing vulnerability for BSD that worsens with illness onset, and there is a distinct relationship between positive urgency and lateral OFC volume among individuals at high versus low risk for BSD. These findings have implications for understanding the expression and development of impulsivity in BSDs. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu