Evaluating the Impact of Fetal Sex on Gestational Diabetes Mellitus Following Interaction with Maternal Characteristics.

Autor: Hooks SK; Department of Preventive Medicine and Population Health, University of Texas Medical Branch-Galveston, Galveston, TX, USA., Abiodun-Ojo O; Department of Internal Medicine, Piedmont Athens Regional Medical Center, Athens, GA, USA., Noah AI; Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA., Hill AV; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Perez-Patron MJ; Department of Epidemiology and Biostatistics, School of Public Health, Texas A&M University, College Station, TX, USA., Menon R; Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA., Taylor BD; Department of Preventive Medicine and Population Health, University of Texas Medical Branch-Galveston, Galveston, TX, USA. bradtayl@utmb.edu.; Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA. bradtayl@utmb.edu.
Jazyk: angličtina
Zdroj: Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2023 Apr; Vol. 30 (4), pp. 1359-1365. Date of Electronic Publication: 2022 Oct 14.
DOI: 10.1007/s43032-022-01106-7
Abstrakt: Fetal-sex-specific changes to placental immunity and metabolism occur in response to obesity. Few studies have determined if fetal sex interacts with maternal characteristics to alter risk of gestational diabetes mellitus (GDM). Among 43,727 singleton pregnancies, we examined the association between male fetal sex and GDM using log-binomial logistic regression to calculate relative risks (RR) and 95% confidence intervals (CI). Interactions were examined between fetal sex and maternal characteristics on the risk of GDM by calculating relative excess risk due to interaction. After adjusting for body mass index, race/ethnicity, maternal age, education, and gravidity, male fetal sex was not associated with GDM (RR adj . 0.95, 95% CI 0.93, 1.04). We found a positive interaction between male fetal sex and obesity (p = 0.04). Nonobese women with male fetuses were less likely to develop GDM, but in the presence of obesity, an opposite trend was observed. There was a positive interaction between male fetal sex and GDM on the risk of preterm delivery < 37-weeks gestation (p = 0.0006). In response to underlying maternal obesity, fetal sex may modify the risk of GDM. In addition, male fetal sex may increase the occurrence of preterm birth among women with GDM.
(© 2022. The Author(s), under exclusive licence to Society for Reproductive Investigation.)
Databáze: MEDLINE
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