A double-blind, randomized, placebo-controlled test of the effects of cannabidiol on fear elicited by a 10% carbon dioxide-enriched air breathing challenge.

Autor: Leen-Feldner EW; University of Arkansas, 216 Memorial Hall, Fayetteville, AR, 72701, USA. eleenfe@uark.edu., Bynion TM; University of Arkansas, 216 Memorial Hall, Fayetteville, AR, 72701, USA., Eglit GML; Canopy Growth Corporation, Smiths Falls, ON, Canada., Bonn-Miller MO; Canopy Growth Corporation, Smiths Falls, ON, Canada., Gournay LR; University of Arkansas, 216 Memorial Hall, Fayetteville, AR, 72701, USA., Feldner MT; Canopy Growth Corporation, Smiths Falls, ON, Canada.
Jazyk: angličtina
Zdroj: Psychopharmacology [Psychopharmacology (Berl)] 2022 Oct 15. Date of Electronic Publication: 2022 Oct 15.
DOI: 10.1007/s00213-022-06258-7
Abstrakt: Objective: A single administration of cannabidiol (CBD) can reduce anxiety during social anxiety inductions. No study, however, has evaluated the impact of CBD on fear responding among humans.
Method: A double-blind, randomized, placebo-controlled trial was undertaken to address this gap in the literature. Specifically, the current study tested a single oral administration of CBD (either 150 mg, 300 mg, or 600 mg), compared to placebo, for reducing fear reactivity to a well-established 5-min administration of 10% carbon dioxide (CO 2 )-enriched air biological challenge. CBD was administered 90 min prior to the challenge. Participants were 61 healthy young adults who self-reported fear continuously during the challenge. Heart rate also was continuously monitored, and panic symptoms were self-reported using the Diagnostic Sensations Questionnaire immediately following the procedure.
Results: Results indicated no effect of condition on self-reported fear, panic symptoms, or heart rate.
Conclusion: This is the first study to document that CBD does not reduce fear reactivity in humans, thereby representing an important extension to research on the effects of CBD.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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