Recent advances in oral delivery of bioactive molecules: Focus on prebiotic carbohydrates as vehicle matrices.

Autor: Falsafi SR; Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran., Bangar SP; Department of Food, Nutrition and Packaging Sciences, Clemson University, Clemson 29634, USA., Chaudhary V; College of Dairy Science and Technology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India., Hosseini E; Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran., Mokhtari Z; Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran., Karaca AC; Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Istanbul, Turkey., Samota MK; Division of Biochemistry, ICAR-Indian Agricultural Research Institute (IARI), New Delhi 12, India., Goswami D; Division of Biochemistry, ICAR-Indian Agricultural Research Institute (IARI), New Delhi 12, India., Krishnan V; Division of Biochemistry, ICAR-Indian Agricultural Research Institute (IARI), New Delhi 12, India., Askari G; Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Rostamabadi H; Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran. Electronic address: rostamabadi@nutr.mui.ac.ir.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2022 Dec 15; Vol. 298, pp. 120074. Date of Electronic Publication: 2022 Sep 07.
DOI: 10.1016/j.carbpol.2022.120074
Abstrakt: Controlled oral delivery of bioactive molecules remains a promising platform for the food and biomedical realm. Nonetheless, there are many bottlenecks to the efficient oral bioactive delivery that necessitates the development of advanced approaches. In recent years, prebiotic carbohydrates have drawn surging interest for targeted bioactive delivery due to their potential of multi-stimuli release mechanisms. Harnessing prebiotic-based vehicles confers novel possibilities for intact oral bioactive delivery, improving their bioavailability and efficacy. This critical review updates state of the art on progresses in oral delivery of natural active agents via prebiotic carbohydrates. We offer the latest advances concerning prebiotic-based vehicles (i.e., pH/time-dependent systems, enzyme-sensitive polymers, and colonic microbiota-dependent vehicles), emphasizing their key attributes to attaining controlled/targeted bioactive delivery to the intended locus. Finally, we discuss safety considerations, challenges, and future perspectives toward advances in the field.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE