Switching and discontinuation of participant-masked randomization to a copper or levonorgestrel intrauterine device when presenting for emergency contraception.

Autor: Kaplan J; Southwest Medical Group Women's & Family Health, Cortez, CO, United States., Turok DK; Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, United States., Gero A; Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, United States., Kaiser JE; Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, United States., Simmons RG; Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, United States., Fay KE; Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, MA, United States. Electronic address: kefay@bwh.harvard.edu.
Jazyk: angličtina
Zdroj: Contraception [Contraception] 2023 Feb; Vol. 118, pp. 109893. Date of Electronic Publication: 2022 Oct 12.
DOI: 10.1016/j.contraception.2022.09.131
Abstrakt: Objectives: Examine intrauterine device (IUD) switching or discontinuation up to 6 months after participant-masked randomization to different IUDs.
Study Design: Participants were randomized 1:1 to the copper T380A or levonorgestrel 52 mg IUD for emergency contraception and informed they could switch IUD type without cost at any time.
Results: Of the 327 subjects allocated to the levonorgestrel IUD, 7 (2.1%) switched their IUD type by 6 months versus 18 (5.5%) of the 328 copper IUD users (RR: 0.4 [95% CI: 0.2, 0.9], p = 0.03). Six-month IUD discontinuation occurred in 34 (10.4%) levonorgestrel and 35 (10.7%) copper IUD users.
Conclusion: Individuals randomly assigned to IUD type at presentation for emergency contraception continue their assigned IUDs at high rates over 6 months.
Implications: While many recruited individuals declined enrollment, those who accepted randomization had high continuation rates; the high continuation and low cross-over supports using IUD randomization as a tool for future investigation. Participants' similar rates of and reasons for switching and discontinuation by IUD type over the study period may impact clinical counseling.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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