PET Imaging of Self-Assembled 18 F-Labelled Pd 2 L 4 Metallacages for Anticancer Drug Delivery.

Autor: Cosialls R; BISi-Bonds group, Dept. of Organic and Pharmaceutical Chemistry, Institut Químic de Sarrià, URL, Vía Augusta 390, 08017, Barcelona, Spain.; Department of Organic and Inorganic Chemistry, Universidad del País Vasco (UPV/EHU), Barrio Sarriena s/n, 48940, Leioa, Bizkaia, Spain., Simó C; CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, 20014, San Sebastián, Gipuzkoa, Spain.; Department of Organic and Inorganic Chemistry, Universidad del País Vasco (UPV/EHU), Barrio Sarriena s/n, 48940, Leioa, Bizkaia, Spain., Borrós S; Grup d'Enginyeria de Materials (GEMAT), Institut Químic de Sarrià,URL, Vía Augusta 390, 08017, Barcelona, Spain., Gómez-Vallejo V; CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, 20014, San Sebastián, Gipuzkoa, Spain., Schmidt C; Chair of Medicinal and Bioinorganic chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748, Garching b. München, Germany., Llop J; CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, 20014, San Sebastián, Gipuzkoa, Spain., Cuenca AB; BISi-Bonds group, Dept. of Organic and Pharmaceutical Chemistry, Institut Químic de Sarrià, URL, Vía Augusta 390, 08017, Barcelona, Spain.; Centro de Innovación en Química Avanzada (ORFEO-CINQA), Spain., Casini A; Chair of Medicinal and Bioinorganic chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748, Garching b. München, Germany.; Munich Data Science Institute, Technical University of Munich, 85748, Garching b. München, Germany.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Jan 12; Vol. 29 (3), pp. e202202604. Date of Electronic Publication: 2022 Nov 23.
DOI: 10.1002/chem.202202604
Abstrakt: To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18 F-labelled [Pd 2 L 4 ] 4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.
(© 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje