NLRP3: Role in ischemia/reperfusion injuries.

Autor:	Ghafouri-Fard S; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Shoorei H; Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran., Poornajaf Y; Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran., Hussen BM; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq.; Center of Research and Strategic Studies, Lebanese French University, Erbil, Iraq., Hajiesmaeili Y; Faculty of Health, York University, Toronto, ON, Canada., Abak A; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Taheri M; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Institute of Human Genetics, Jena University Hospital, Jena, Germany., Eghbali A; Anesthesiology Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2022 Sep 27; Vol. 13, pp. 926895. Date of Electronic Publication: 2022 Sep 27 (Print Publication: 2022).
DOI:	10.3389/fimmu.2022.926895
Abstrakt:	NLR family pyrin domain containing 3 (NLRP3) is expressed in immune cells, especially in dendritic cells and macrophages and acts as a constituent of the inflammasome. This protein acts as a pattern recognition receptor identifying pathogen-associated molecular patterns. In addition to recognition of pathogen-associated molecular patterns, it recognizes damage-associated molecular patterns. Triggering of NLRP3 inflammasome by molecules ATP released from injured cells results in the activation of the inflammatory cytokines IL-1β and IL-18. Abnormal activation of NLRP3 inflammasome has been demonstrated to stimulate inflammatory or metabolic diseases. Thus, NLRP3 is regarded as a proper target for decreasing activity of NLRP3 inflammasome. Recent studies have also shown abnormal activity of NLRP3 in ischemia/reperfusion (I/R) injuries. In the current review, we have focused on the role of this protein in I/R injuries in the gastrointestinal, neurovascular and cardiovascular systems. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Ghafouri-Fard, Shoorei, Poornajaf, Hussen, Hajiesmaeili, Abak, Taheri and Eghbali.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu