Effect of monosodium glutamate on serum sex hormones and uterine histology in female rats along with its molecular docking and in-silico toxicity.
| Autor: | Abdulghani MAM; Faculty of Medicine and Health Sciences, University of Science and Technology, Aden, Yemen.; Department of Pharmacology & Toxicology, Unaizah College of Pharmacy, Qassim University, Al Qassim 51911, Saudi Arabia., Alshehade SA; Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 USM Penang, Malaysia.; Department of Pharmacology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia., Kamran S; Department of Pharmacology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia., Alshawsh MA; Department of Pharmacology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia. |
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| Jazyk: | angličtina |
| Zdroj: | Heliyon [Heliyon] 2022 Oct 05; Vol. 8 (10), pp. e10967. Date of Electronic Publication: 2022 Oct 05 (Print Publication: 2022). |
| DOI: | 10.1016/j.heliyon.2022.e10967 |
| Abstrakt: | Monosodium glutamate (MSG) is commonly used worldwide as a food flavour enhancer by the food industry. The current study investigated the in vivo toxic effects of MSG on the uterus in adult female Sprague Dawley rats and in vitro using MCF-7 and MDA-MB-231 cells, computational toxicity and molecular docking. The average levels of progesterone and oestrogen in the MSG-treated animals significantly altered. Besides, the average uterine lumen area (μm 2 ) was smaller than the control group. MSG showed high-affinity binding to acetylcholine receptors and disrupted the normal nerve signal with a predicted LD50 of 4500 mg/kg. MSG also demonstrated good binding affinity to human oestrogen receptors beta and some other proteins that have an oxidative stress role in the female reproductive organs. Therefore, a precaution should be taken when utilising this compound, especially for females under the risk factor of hormonal abnormality. Competing Interests: The authors declare no conflict of interest. (© 2022 Published by Elsevier Ltd.) |
| Databáze: | MEDLINE |
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