Role of Nanotechnology in Overcoming the Multidrug Resistance in Cancer Therapy: A Review.

Autor: Mir SA; Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, India., Hamid L; Department of Zoology, University of Kashmir, Hazratbal, Srinagar 190006, India., Bader GN; Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, India., Shoaib A; Department of Pharmacy Practice, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia., Rahamathulla M; Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia., Alshahrani MY; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia., Alam P; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia., Shakeel F; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2022 Oct 05; Vol. 27 (19). Date of Electronic Publication: 2022 Oct 05.
DOI: 10.3390/molecules27196608
Abstrakt: Cancer is one of the leading causes of morbidity and mortality around the globe and is likely to become the major cause of global death in the coming years. As per World Health Organization (WHO) report, every year there are over 10 and 9 million new cases and deaths from this disease. Chemotherapy, radiotherapy, and surgery are the three basic approaches to treating cancer. These approaches are aiming at eradicating all cancer cells with minimum off-target effects on other cell types. Most drugs have serious adverse effects due to the lack of target selectivity. On the other hand, resistance to already available drugs has emerged as a major obstacle in cancer chemotherapy, allowing cancer to proliferate irrespective of the chemotherapeutic agent. Consequently, it leads to multidrug resistance (MDR), a growing concern in the scientific community. To overcome this problem, in recent years, nanotechnology-based drug therapies have been explored and have shown great promise in overcoming resistance, with most nano-based drugs being explored at the clinical level. Through this review, we try to explain various mechanisms involved in multidrug resistance in cancer and the role nanotechnology has played in overcoming or reversing this resistance.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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