Assessment of the Effects of Triticonazole on Soil and Human Health.

Autor: Roman DL; Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West University of Timisoara, 16 Pestalozzi, 300115 Timisoara, Romania.; Advanced Environmental Research Laboratories (AERL), 4 Oituz, 300086 Timisoara, Romania., Voiculescu DI; Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West University of Timisoara, 16 Pestalozzi, 300115 Timisoara, Romania.; Advanced Environmental Research Laboratories (AERL), 4 Oituz, 300086 Timisoara, Romania., Matica MA; Department of Chemistry-Biology, Institute for Advanced Environmental Research (ICAM), West University of Timisoara, Oituz 4C, 300086 Timisoara, Romania., Baerle V; Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West University of Timisoara, 16 Pestalozzi, 300115 Timisoara, Romania.; Advanced Environmental Research Laboratories (AERL), 4 Oituz, 300086 Timisoara, Romania., Filimon MN; Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West University of Timisoara, 16 Pestalozzi, 300115 Timisoara, Romania.; Advanced Environmental Research Laboratories (AERL), 4 Oituz, 300086 Timisoara, Romania., Ostafe V; Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West University of Timisoara, 16 Pestalozzi, 300115 Timisoara, Romania.; Advanced Environmental Research Laboratories (AERL), 4 Oituz, 300086 Timisoara, Romania., Isvoran A; Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West University of Timisoara, 16 Pestalozzi, 300115 Timisoara, Romania.; Advanced Environmental Research Laboratories (AERL), 4 Oituz, 300086 Timisoara, Romania.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2022 Oct 03; Vol. 27 (19). Date of Electronic Publication: 2022 Oct 03.
DOI: 10.3390/molecules27196554
Abstrakt: Triticonazole is a fungicide used to control diseases in numerous plants. The commercial product is a racemate containing (R)- and (S)-triticonazole and its residues have been found in vegetables, fruits, and drinking water. This study considered the effects of triticonazole on soil microorganisms and enzymes and human health by taking into account the enantiomeric structure when applicable. An experimental method was applied for assessing the effects of triticonazole on soil microorganisms and enzymes, and the effects of the stereoisomers on soil enzymes and human health were assessed using a computational approach. There were decreases in dehydrogenase and phosphatase activities and an increase in urease activity when barley and wheat seeds treated with various doses of triticonazole were sown in chernozem soil. At least 21 days were necessary for the enzymes to recover the activities. This was consistent with the diminution of the total number of soil microorganisms in the 14 days after sowing. Both stereoisomers were able to bind to human plasma proteins and were potentially inhibitors of human cytochromes, revealing cardiotoxicity and low endocrine disruption potential. As distinct effects, (R)-TTZ caused skin sensitization, carcinogenicity, and respiratory toxicity. There were no significant differences in the interaction energies of the stereoisomers and soil enzymes, but (S)-TTZ exposed higher interaction energies with plasma proteins and human cytochromes.
Competing Interests: The authors declare no conflicts of interest.
Databáze: MEDLINE
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