Chemical Profile and Biological Activities of Essential Oil from Piper arboreum for Development and Improvement of Mouthwash.

Autor: Matias EFF; Department of Biomedicine, University Center Dr. Leão Sampaio, Juazeiro do Norte 63040-405, CE, Brazil.; Dentistry Course, CECAPE College, Juazeiro do Norte 63024-015, CE, Brazil., Pereira APD; Dentistry Course, CECAPE College, Juazeiro do Norte 63024-015, CE, Brazil., Braz AVO; Dentistry Course, CECAPE College, Juazeiro do Norte 63024-015, CE, Brazil., Rodrigues MC; Dentistry Course, CECAPE College, Juazeiro do Norte 63024-015, CE, Brazil., Silva JL; Dentistry Course, CECAPE College, Juazeiro do Norte 63024-015, CE, Brazil., Maia PAA; Dentistry Course, CECAPE College, Juazeiro do Norte 63024-015, CE, Brazil., Santos SCD; Department of Chemistry, Regional University of Blumenau, Rua Antônio da Veiga, 140, Blumenau 89030-903, SC, Brazil., Rebelo RA; Department of Chemistry, Regional University of Blumenau, Rua Antônio da Veiga, 140, Blumenau 89030-903, SC, Brazil., Begnini IM; Department of Chemistry, Regional University of Blumenau, Rua Antônio da Veiga, 140, Blumenau 89030-903, SC, Brazil., Silva LED; Post-Graduate Programme in Sustainable Territorial Development, Paraná Federal University, Matinhos 83260-000, PR, Brazil., Amaral WD; Post-Graduate Programme in Sustainable Territorial Development, Paraná Federal University, Matinhos 83260-000, PR, Brazil., Kowalska G; Department of Tourism and Recreation, University of Life Sciences in Lublin, 15 Akademicka Street, 20-950 Lublin, Poland., Rowiński R; Department of Tourism and Recreation, University of Life Sciences in Lublin, 15 Akademicka Street, 20-950 Lublin, Poland., Hawlena J; Department of Tourism and Recreation, University of Life Sciences in Lublin, 15 Akademicka Street, 20-950 Lublin, Poland., Kowalski R; Department of Analysis and Evaluation of Food Quality, University of Life Sciences in Lublin, 8 Skromna Street, 20-704 Lublin, Poland., Coutinho HDM; Department of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, CE, Brazil., Alencar VRCT; Department of Biomedicine, University Center Dr. Leão Sampaio, Juazeiro do Norte 63040-405, CE, Brazil.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2022 Sep 28; Vol. 27 (19). Date of Electronic Publication: 2022 Sep 28.
DOI: 10.3390/molecules27196408
Abstrakt: Studies show that more consumers are using natural health products in the modern world. We have noticed a growing demand in markets and the professional community for mouthwashes that contain natural compounds. The objective of this study was to assess the chemical characterization and microbiological potential of the essential oil Piper arboreum (EOPa) to provide data to enable the development of a low-cost mouthwash. The evaluation of the antibacterial and bacterial resistance modulating activity was performed by the microdilution method to determine the minimum inhibitory concentration. The chemical components were characterized by gas chromatography coupled with mass spectrometry, which identified 20 chemical constituents, with caryophyllene oxide being one of the major compounds. The EOPa showed an MIC ≥ 1024 µg/mL for all bacterial strains used in the tests. When evaluating the modulating activity of EOPa combined with chlorhexidine, mouthwash and antibiotics against the bacterial resistance, the oil limited synergistic activity between the MIC of the products tested in combination (37% to 87.5%). Therefore, we recommend expanding the tests with greater variation in the EOPa concentration and the products used, as well as toxicity assessments and in vivo testing, with the purpose of the development of a possible low-cost mouthwash base that is accessible to the most vulnerable populations.
Databáze: MEDLINE
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