| Autor: |
Chanphai P; Department of Chemistry, Biochemistry and Physics, University of Québec at Trois-Rivières, Trois-Rivières, QC G9A 5H7, Canada., Bérubé G; Department of Chemistry, Biochemistry and Physics, University of Québec at Trois-Rivières, Trois-Rivières, QC G9A 5H7, Canada., Tajmir-Riahi HA; Department of Chemistry, Biochemistry and Physics, University of Québec at Trois-Rivières, Trois-Rivières, QC G9A 5H7, Canada. |
| Jazyk: |
angličtina |
| Zdroj: |
Molecules (Basel, Switzerland) [Molecules] 2022 Sep 23; Vol. 27 (19). Date of Electronic Publication: 2022 Sep 23. |
| DOI: |
10.3390/molecules27196264 |
| Abstrakt: |
The conjugation of chitosan 15 and 100 KD with anticancer drugs cis- and trans-Pt (NH 3 ) 2 Cl 2 (abbreviated cis-Pt and trans-Pt) were studied at pH 5-6. Using multiple spectroscopic methods and thermodynamic analysis to characterize the nature of drug-chitosan interactions and the potential application of chitosan nanoparticles in drug delivery. Analysis showed that both hydrophobic and hydrophilic contacts are involved in drug-polymer interactions, while chitosan size and charge play a major role in the stability of drug-polymer complexes. The overall binding constants are K ch-15-cis-Pt = 1.44 (±0.6) × 10 5 M -1 , K ch-100-cis-Pt = 1.89 (±0.9) × 10 5 M -1 and K ch-15-trans-Pt = 9.84 (±0.5) × 10 4 M -1 , and K ch-100-trans-Pt = 1.15 (±0.6) × 10 5 M -1 . More stable complexes were formed with cis-Pt than with trans-Pt-chitosan adducts, while stronger binding was observed for chitosan 100 in comparison to chitosan 15 KD. This study indicates that polymer chitosan 100 is a stronger drug carrier than chitosan 15 KD in vitro. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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